摘要
为了探讨非亲缘HLA相合供者骨髓移植 (UD BMT)治疗骨髓增生异常综合征 (MDS)的可行治疗方案和疗效 ,采用HLA配型相合的非亲缘骨髓移植治疗 1例骨髓增生异常综合征 难治性血细胞减少伴多系病态造血(MDS RCMD)男性患者 ,31岁。预处理方案为马利兰、环磷酰胺、阿糖胞苷、甲基环己亚硝脲和抗胸腺细胞球蛋白。以霉酚酸酯、环孢菌素A加短疗程的甲氨喋呤预防移植物抗宿主病 (GVHD)。结果显示 ,移植后 10天中性粒细胞 (0 .5× 10 9 L ,2 0天血小板升至 5 8× 10 9 L ,3个月血红蛋白升至 114g L ,无GVHD发生 ;移植后无病存活时间已达 9个月。结论 :非血缘HLA相合骨髓移植治疗骨髓增生异常综合征是可行而且有效的。
To explore feasibility and efficacy of unrelated HLA matched donor marrow transplantation in treatment of myelodysplastic syndrome,one case (male,31 years old) of myelodysplastic syndrome-refractory cytopenia with multilineage dysplasia (MDS-RCMD) has been received unrelated HLA-matched donor transplantation. Busulfan,cyclophosphamide,Ara-C,MeCCNU and antithymocyte globulin (ATG) were used for preparative regimen. Mycophenolate mofetile,cyclosporin A and short-term methotrexate were used for graft-versus-host disease prophylaxis. The results showed that neutrophil of >0.5×109/L,platelet of 58×109/L and hemoglobin of 114 g/L were observed at 10,20 days and 3 months respectively post transplantation. Disease-free survival without GVHD was 9 months. In conclusion,unrelated HLA matched donor marrow transplantation is an effective approach for treatment of patients with MDS.
出处
《中国实验血液学杂志》
CAS
CSCD
2004年第3期378-380,共3页
Journal of Experimental Hematology
基金
全军"十五"医药卫生科研基金资助项目
编号0 1Q0 63
