摘要
目的 :探讨肿瘤坏死因子 ( TNF- α)、白细胞介素 - 6( IL- 6)、白细胞介素 8( IL- 8)在慢性阻塞性肺病 ( COPD)急性发作期的作用及临床意义。方法 :COPD患者 68例 ,用放射免疫分析法 ( RIA)测定其血清 TNF-α、IL - 6、IL- 8水平。结果 :COPD急性发作期非呼吸衰竭组、呼吸衰竭组血清TNF-α、IL- 8水平明显增高 ,且与病情严重程度呈正相关 ;呼吸衰竭组血清 IL - 6水平虽高于缓解组 ,但明显低于非呼吸衰竭组。结论 :TNF- α、IL- 6、IL- 8参与了 COPD患者的炎症过程 ,其血清水平有助于对 COPD急性发作期患者病情及预后监测。
Objective: To study the variation and significance of TNF α, IL 6, IL 8 in cases with acute COPD. Methods:68 cases were chosen to be observed during Feb. 2002 to Agu. 2003, whose serum TNF α, IL 6, IL 8 were determined by RIA. Results: The levels of serum TNF α and IL 8 rose obviously in acute COPD, and the levels were connected to the serious condition of disease. The level of serum IL 6 in respiratory failure group was higher than that in relief group, while obviously lower than that in respiratory non failure group. Conclusion:TNF α, IL 6, IL 8 have taken part in the inflammation activity, whose levels have good effect on determining the condition and prognosis about acute COPD.
出处
《浙江中西医结合杂志》
2004年第6期343-344,共2页
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
