摘要
研究雌激素受体 ( ER)敲除小鼠脑内 ,ERα和 ERβ在介导内侧杏仁核中白细胞介素 1β( IL -1β)表达的作用。IL-1β表达有显著的性别差异 ,并且在 ER敲除小鼠含量减少。细菌脂多糖 ( L PS)或卵巢切除能够促进野生型和 ERβ敲除小鼠 ( BERKO) IL-1β表达 ,但对 ERα敲除小鼠 ( ERKO)无作用。相似的是 ,外源性雌激素能抑制野生型和 BERKO小鼠 IL -1β表达 ,后者时间稍有延搁 ,但对 ERKO IL-1β表达没有影响。结果表明 ,ERα是内侧杏仁核 IL -1β表达调节的重要机制 ,提示
IL-1β expression in the medial amygdaloid nucleus (MeA) from ERs (estrogen receptors) knockout mice was carried out to determine the roles of ERα and ERβ in mediating IL-1β expression in the brain. There was clear sex difference of IL-1β expression in MeA and IL-1β expression was reduced in ERs-knockout mice. Either LPS or ovariectomy could enhance IL-1β expression in both wild-type (WT) and ERβ knockout mice (BERKO), but not in ERα knockout mice (ERKO). Similarly, exogenous estrogen could inhibit IL-1β expression in MeA both from WT and BERKO mice, with the later in a lagged manner, but not from ERKO. The results clearly establish that ERα is a critical mechanism for IL-1β expression in MeA, implying for a selective targeting of ERs in the treatment and prevention of neural dysfunction.
出处
《神经解剖学杂志》
CAS
CSCD
北大核心
2004年第3期257-261,共5页
Chinese Journal of Neuroanatomy
