摘要
本研究应用光镜及透射电镜技术,观察了三氯化镧(LaCl_3)对小鼠肝脏形态结构的影响。结果表明,静脉注射LaCl_32天后,1mg/kg·w组枯否氏细胞中仅见镧沉积形成的致密体;5mg/kg·w组镧进一步沉积于肝细胞;20mg/kg·w组出现肝细胞广泛的变性及坏死,且于给药后 72h左右动物死亡;80mg/kg·w组除糖原减少外,肝脏结构无著变。静注 10天后,1mg/ks·w组、5mg/kg·w组组肝细胞恢复正常,80ms/kg·w组可出现小叶内点状坏死,局部糖原消失。腹腔注射,80mg/kg·w组于第10天可出现肝小叶内点状坏死。
The effects of lanthanum trichloride (Lads) on mouse liver were studied with light and electron microscopy. The results showed that on the 2nd day after intravenous injection of LaCl3. dense bodies formed by La deposition were found in Kupffer's cells in the 1mg/kg · w group; La deposition was also found in hepatocytes in the 5mg/kg · w group; extensive degeneration and necrosis of hepatocytes were observed in the 20mg/kg · w group, and furthermore, all the mice in this group died on the 3rd day; but in the 80mg/kg · w group, the liver structure changed little expect reduction of glyycogen. On the 10th day, the liver structures recovered to normal in the 1mg/kg · w and the 5mg/ kg · w groups. While intralobular spot necrosis and local disappearence of glycogen were visible in the 80mg/kg · w group.
出处
《白求恩医科大学学报》
CSCD
1993年第5期438-440,共3页
Journal of Norman Bethune University of Medical Science
基金
国家自然科学基金
关键词
镧
毒性
肝
肝疾病
化学诱导
lanthanum/TO
liver/UL
liver diseases/CI
acute hepatonecrosis
