摘要
本文报道了胆囊收缩素(CCK)对抗维生素B_(12)(VitB_(12))的镇痛作用。结果表明,采用小剂量(ng级)侧脑室注射CCK-8,可明显对抗VitB_(12)的镇痛作用,而且表现有剂量效应关系。从而证明小剂量CCK-8在痛觉调制中,有较强的抗阿片的镇痛作用;从另一角度证明,VitB_(12)的镇痛作用是通过与脑内阿片受体结合而实现的。
It is reported in this paper that CCK-8 could antagonize the analgesic effect of vitamin B12. Small doses (4- 12ng) of CCK- 8 injected into the lateral ventricles could obviously antagonize the analgesic effect of vitamin B12, presenting a clear dose-dependent effect relationship.Therfore, these results showed that small doses of CCK-8 had a strong action opposing to the analgesic effect of opiate in the integration of pain sensation; on the other hand, it was also certified that the analgesic effect of B12 was really accomplished by its binding with the opiate receptors in the brain.
出处
《白求恩医科大学学报》
CSCD
1993年第4期334-335,共2页
Journal of Norman Bethune University of Medical Science
关键词
胆囊收缩素
维生素B12
药理
止痛
CCK -8/PD
vitamin B12/PD
analgesia/TD
receptors, drug
