摘要
本实验观察了放疗与复方天仙胶囊合并应用对小鼠肿瘤的影响,结果小鼠肿瘤明显缩小,疗效为单纯放疗的1.89倍;合并应用组瘤细胞坏死显著,可见炎细胞浸润,瘤细胞膜相结构损伤的早并且显著加重。提示,瘤细胞的膜相结构可能为复方天仙胶囊中某药成份增敏作用的靶点;另外,促进炎细胞浸润也可能是其辐射增敏的表现形式之一。
It was found in this study that 10 Gy radiation combined with Compound Tian-Xi-an Capsule (on the 3th day of tumor implantation; at a dosage of 2. 5g/kg P. O. once everyday for 3 days) promoted tumour regression significantly compared with 10 Gy radiation alone, with the therapeutic efficacy 1. 89 times more than that of radiation alone. In the combined group, it was found that necrosis of the tumour cells was more severe, and there were many inflammatory cells surrounding the tumour. In addition, changes in the membranous structure and mitochondria appeared earlier and were more serious, indicating that membranous structure may be the target site of enhanced sensitivity of Compound Tian-Xian Capsule. Promotion of infiltration of inflammatory cells may be one of the expression forms of enhanced radiation sensitivity.
出处
《白求恩医科大学学报》
CSCD
1993年第2期159-161,共3页
Journal of Norman Bethune University of Medical Science
关键词
复方
天仙胶囊
放射疗法
肿瘤
小鼠
Radiotherapy Compound Tian-Xian Capsule Light and electron microscopy
