期刊文献+

地塞米松联合新斯的明用于前列腺摘除术后镇痛的临床研究

暂未订购
导出
摘要 目的 :研究在前列腺摘除术后用地塞米松硬膜外给药对新斯的明镇痛效果和不良反应的影响。方法 :硬膜外阻滞下经膀胱前列腺摘除术患者 4 0例 ,随机分为两组 :A组 2 0例 ,术毕硬膜外注入新斯的明 1mg加生理氯化钠共 8mL ;B组 2 0例在A组基础上加地塞米松 5mg。对两组患者分别在手术结束后 4小时、 8小时、 12小时、 2 4小时、 4 8小时进行视觉模拟疼痛评分 ,并比较两组的不良反应发生率。结果 :两组术后 2 4小时内各时段疼痛评分差异无统计学意义 (P >0 0 5 ) ;但在术后 4 8小时 ,B组的疼痛评分 [(3 5± 1 6 )分 ]比A组 [(5 0± 1 8)分 ]低 (P <0 0 5 ) ;B组的不良反应发生率明显低于A组(P <0 0 5 )。结论 :在前列腺摘除术后用地塞米松硬膜外给药不仅能增强新斯的明的镇痛作用 ,而且显著降低恶心、呕吐。
出处 《新医学》 北大核心 2004年第6期350-351,共2页 Journal of New Medicine
  • 相关文献

参考文献4

二级参考文献10

  • 1[1]The Italian Group for Antiemetic Research.Dexamethasone,Granisetron,or both for the prevention of nausea and vomiting during chemotherapy for cancer.New Eng J Med,1995,332:1-5.
  • 2[2]Fredrikson M,Hursti T,Fuest CJ et al.Nausea in cancer chemotherapy is inversely related to urinary cortisol excretion.Br J Cancer,1992,65:779-780.
  • 3[3]Lopez-Olaondo L,Carrascosa F,Pueyo FJ, et al.Combination of ondansetron and dexamethasone in the prophylaxis of postoperative nausea and vomiting.Br J Anaesth,1996,76:835-840.
  • 4[4]Liu K,Hsu CC and Chia YY.Effect of dexamethasone on postoperative emesis and pain.Br J Anaesth,1998,80:85-86.
  • 5[6]Brunton LL.Antiemetic Agents.In:Hardman JG and Limbird LE,eds.Goodman & Gilman's the Pharmacological Basis of Therapeutics.Ninth ed.New York:McGraw-Hill companies Inc,1996,930-931.
  • 6[7]Wang JJ,Ho ST,Lee SC, et al.The prophylactic effect of dexamethasone on postoperative nausea and vomiting in women undergoing thyroidectomy:A comparison of droperidol with saline.Anesth Analg,1999,89:200-203.
  • 7[8]Wang JJ,Ho ST,Liu YH et al.Dexamethasone decrease epidural morphine-related nausea and vomiting.Anesth Analg,1999,89:117-120.
  • 8[9]Aapro MS,Plezia PM,Alberts DS,et al.Double-blind cross-over study of the antiemetic efficacy of high-dose dexamethasone versus high-dose metoclopramide.J Clin Oncology,1984,2:466-471.
  • 9[10]Young SN.Mechanisms of decline in rat brain 5-hydroxytryptamine after induction of liver tryptophan pyrrolase by hydrocortisone:roles of tryptophan catabolism and kynurenine synthesis.Br J Pharmacol,1981,74:695-698.
  • 10[12]Baxendale BR,Vater M, Lavery KM.Dexamethasone reduces pain and swelling following extraction of third molar teeth.Anaesthsia, 1993,48:961-964.

共引文献68

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部