摘要
噻唑烷二酮衍生物是一类新型的抗糖尿病药物,可直接改善组织对胰岛素的敏感性,其不仅可持久稳定地降低血糖,同时可减轻糖尿病大血管和微血管并发症的危险因子。本文主要对罗格列酮的作用机制、降血糖作用和降血管以外的可能保护作用进行简要综述。
出处
《国外医学(老年医学分册)》
2004年第3期132-135,共4页
Foreign Medical Sciences(Geriatrics)
参考文献21
-
1Boyle PJ, King AB, OlanskyL et al. Effects of pioglitazone and rosiglitazone on blood lipid levels and glycemic control in patients with type 2 diabetes mellitus: a restrospective review of randomly selected medical records. Clin Ther, 2002;2493: 378~ 39
-
2Hallsten K, Virtanen KA, Lonnqvist F et al. Rosiglitazone not metformin enhances insulin - and exercise - stimulated skeletal muscle glucose uptake in patients with newly diagnosed type 2 diabetes. Diabetes, 2002; 51 (12): 3479~3485
-
3A Diabetes Outcome Progression Trial (ADOPT): an international multicenter study of the comparative efficacy of rosiglitazone, glyburide, and metformin in recently diagnosed type 2diabetes. Diabetes Care, 2002; 25 (10): 1734~1743
-
4Lebovitz HE, Kreider M, Freed MI. Evaluation of liver function in type 2 diabetic patients during clinical trial: evidence that rosiglitazone does not cause hepatic dysfunction.Diabetes Care, 2002; 25 (5): 815~821
-
5Matthews DR. Guidance on rosiglitazone for type 2 diabetes mellitus. Lancet, 2001; 357 (9254): 481
-
6Stumvoll M, Haring MH. Glitazones: Clinical effects and molecular mechanisms. Ann Med, 2002; 34 (3): 217-224
-
7Gomez- Perrez FJ, Fanfhanel- Salmon G, Antonio- Barbose J et al. Efficacy and safety of rosiglitazone plus metformin in Mexicans with type 2 diabetes. Diabetes Metab Res Rev, 2002; 18 (2): 127-134
-
8Wolffenbuttel BH, Gomis R, Squatrito S et al. Addition of low dose rosiglitazone to sulphonylurea therapy improves glycemic control in type 2 diabetic patients. Diabet Med,2000; 17 (1): 40-47
-
9Buch HN, Baskar V, Barton DM et al. Combination of insulin and thiazolidinedione therapy in massively obese patients with type2 diabetes. Diabet Med, 2002; 19 (7): 572-574
-
10Raskin P, Re1ndell M, Riddle MC et al. A randomized trial of rosiglitazone therapy in patients with inadequately controlled insulin- treated type 2 diabetes. Diabetes Care, 2001; 24(7): 1226-1232
同被引文献40
-
1代谢综合征发病机制的探讨[J].国外医学(心血管疾病分册),2004,31(5):311-312. 被引量:2
-
2王俊宏,刘艳晓,董书会.罗格列酮联合胰岛素治疗单用胰岛素控制血糖不佳的2型糖尿病疗效观察[J].中国误诊学杂志,2004,4(2):274-275. 被引量:5
-
3林青,孙璟,金翠燕,吴霖.罗格列酮对2型糖尿病病人血糖、血压、血脂的影响[J].中国新药与临床杂志,2004,23(12):871-873. 被引量:10
-
4林丽香,陈刚.从代谢综合征探讨2型糖尿病治疗新思路及新策略[J].实用糖尿病杂志,2005,1(2):59-61. 被引量:2
-
5姚军,郭晓蕙,张俊清,惠岩,陈澜.2型糖尿病患者应用吡格列酮治疗前后血清C反应蛋白的改变[J].中华糖尿病杂志(1006-6187),2005,13(3):209-212. 被引量:22
-
6Martens FM,Visseren FL,Lemay J,et al.Metabolic and additional vascular effects of thiazolidinediones.Drugs,2002,62:1463-1480.
-
7Mortensen RF.C-reactive protein,inflammation,and innate immunity.Immunol Res,2001,24:163-176.
-
8Pasceri V,Willerson JT,Yeh ET.Direct proinflammatory effect of C-reactive protein onhuman endothelial cell.Circulation,2002,102:2165-2167.
-
9Kern P,Ranganathan S,Li C,et al.Adipose tissue tumor necrosis factor and interleukin-6 expression in human odesity and insulin resistance.Am J Physiol Endocrinol Metab,2001,280:E745-E751.
-
10Venugopal SK,Devaraj S,Yuhanna I,et al.Demonsiration that C-reactive protein decrease eNOS expression and bioactivity in human aortic endothelial cells.Circulation,2002,106:1439-1441.
引证文献3
-
1余进东,张咏.罗格列酮联合胰岛素治疗2型糖尿病的临床观察[J].临床医学,2006,26(6):64-65. 被引量:1
-
2郭进,王风.有降压作用的非传统降压药物研究现状及意义[J].临床荟萃,2007,22(5):374-377.
-
3杨孟雪,李显文,于江泳,高琳.噻唑烷二酮对2型糖尿病的代谢综合征患者C反应蛋白、纤维蛋白原的影响[J].陕西医学杂志,2009,38(7):809-812. 被引量:1
-
1崔金钟.凝血因子的种类[J].中国高教论丛,2003,25(3):30-31.
-
2王艳.一次走不了一百米 下肢动脉有问题[J].人人健康,2010(17):29-29.
-
3胡志鹏.赖诺普利治疗高血压的疗效观察[J].中国民族民间医药,2010,19(9):38-38.
-
4凌伟,林晓.苯磺酸氨氯地平治疗原发性轻中度高血压疗效观察[J].基层医学论坛,2010,14(16):527-528. 被引量:3
-
5朱恩飞.六味五灵片联合派罗欣治疗HbeAg阳性慢性乙型肝炎的临床观察[J].中国医药科学,2011,1(22):67-67. 被引量:2
-
6石雯之.苯磺酸氨氯地平联合卡托普利治疗原发性高血压疗效观察[J].中外医疗,2012,31(16):86-86. 被引量:1
-
7李昕.雷贝拉唑钠治疗199例消化性溃疡患者的临床疗效探讨[J].中国医药导报,2008,5(35):150-151. 被引量:6
-
8靖大道,汪佩文,陈洁,周怡和,王宁宁,王兴鹏.以雷贝拉唑为基础的短程三联或四联疗法根除幽门螺杆菌的随机对照研究[J].中华消化杂志,2004,24(4):250-251. 被引量:18
-
9王春义,王秋月.苯磺酸氨氯地平治疗原发性高血压的疗效观察[J].中国当代医药,2009,16(10):61-62. 被引量:2
-
10蒋丹斌,单际平,王福生.雷贝拉唑钠治疗消化性溃疡的疗效观察[J].现代医药卫生,2003,19(4):388-389.