摘要
目的 探讨云南引种阳春砂与阳春砂主要成分挥发油的药理活性。方法 针对砂仁药材的功能主治,设计了砂仁主要药效成分挥发油止泻、镇痛和对离体兔空肠自发活动影响的药效学实验。建立10％番泻叶致诱导的小鼠腹泻模型、0.6％醋酸溶液致小鼠扭体等模型,观察云南引种阳春砂与阳春砂主要成分挥发油的药理作用。结果 云南引种阳春砂的挥发油均有剂量依赖性的止泻作用,其中剂量为270 mg·kg-1作用较明显;镇痛作用与对照组相比差异不明显;两者对兔离体空肠自发活动均有明显的抑制作用。结论 云南引种阳春砂与阳春砂药理活性无明显差异,为评价引种阳春砂的质量提供一些科学的依据。
OBJECTIVE: To study the pharmacological effects of volatile oils of Yunnan introduced Amomum villosum and Amomum villosum. METHODS: Pharmacological models such as diarrhea caused by 10% aqueous extract of Folium Sennae and pain caused by 0.6% acetic acid, as well as inner pressure of rabbits' small intestine were applied. RESULTS: Both of Yunnan introduced Amomum villosum and Amomum villosum showed dose-dependant antidiarrhea effects. When the content of volatile oils was 270 mg·kg-1, their effects were markedly enhanced (P < 0.01). There was no effect in relieving pain. Both had the effect of restraing the movements of small intestine smooth muscle. CONCLUSION: There were few differences between Yunnan introduced Amomum villosum and Amomum villosum in biological activities. This study can be applied to evaluate the quality of Yunnan introduced Amomum villosum.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2004年第5期342-344,共3页
Chinese Pharmaceutical Journal
基金
广东省"十五"重点科技攻关计划项目(A301020101)
关键词
云南引种阳春砂
阳春砂
药理活性
挥发油
豆蔻属
Acetic acid
Biological organs
Drug dosage
Drug products
Living systems studies
Medical problems
Muscle
