摘要
肝脏是物质代谢的枢纽,是氨基酸代谢的中心器官,当肝脏由于各种原因发生损伤时,可导致体内复杂的代谢紊乱,尤其是氨基酸代谢的紊乱,这已被大量的动物实验及临床研究所证实。关于肝损伤时氨基酸代谢变化的研究近十年来进展迅速,文献报道很多,一般认为肝损伤时存在有两种类型的血浆氨基酸失衡模式,一是慢性肝损伤的血浆氨基酸失衡模式,另一种就是急性肝损伤时的血浆氨基酸失衡模式。前者以支链氨基酸(Brached chain Amino acid,
Liver is a centre organ for metablism of amino acid.
There are complex metablism disturbances of material, especially amino
acid, when liver has damaged due to varie causes. progress in exploring
on metablism of amino acid in acute Liver damage is rapidly. Generally
speaking, there are two different amino aeid patterns in liver disease
(1) chronic tiver disease With acute exacerbation, a pcasma amino acidv
pattern(2)Acute fulminant hepatitiius includes a generalzid hyperaminoaciare
demia pattern. This. paper will mainly cntroduce progress in these fileds that
imbalance of plasma amino acid, disturbances metabtism of amion acid
and hepatic encephalopathy, and the value of amino acid analysis for
diagnosis or therapy in liver disease, and so on in recent 10 years.
