摘要
作者用计算机图像分析系统测定了50例卵巢恶性肿瘤细胞DNA含量,并分析其与患者的临床分期及预后关系。结果提示:卵巢恶性肿瘤细胞DNA含量可分为3种类型,3型各组患者的5年存活率分别为89％、21％、0.07％(P<0.005),平均存活时间分别为282.83周、110.43周、15.04周(P<0.01)。本文还比较了同一病理分级但不同DNA分型的患者存活率。计算了长期存活者异倍体细胞少于50％,高异倍体细胞少于10％(P<0.01)。结果表明:患者存活率随卵巢肿瘤细胞DNA含量增加而降低,DNA含量是判断卵巢恶性肿瘤临床生物学行为的一个客观指标。
50 cases ovarian carcinomas were examined with respect to DNA content of the tumor cells by means of image analysis technology(IAT) and andyzed the relationship between DAN content and clinical staging and prognosis of patients. Result shown that ovarian carcinomas fell into 3 type groups on the basis of DNA content. 5-year survival rate of patient in DNA Ⅰ, Ⅱ, Ⅲ types was 89%, 21%and 0 .007% (P < 0. 005) and average survival times was 282.83, 110.43 and 15.04 weeks respectively(P<0.0 1). On the other hand, the study compared survival rate of patients with different DNA content in same histopathologic grading 1 We found that % tumor cell with DNA 5C and 8C of the long term survival patients was 50%, 10% respectively. Survival rate of the patients was decreased with DNA content increasing, the result of study suggested that the DNA content of ovarian carcinoma cell be an objective index to evaluate the biological and clicical behavior course of the patents with tumor.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1993年第2期111-114,共4页
Chinese Journal of Cancer
关键词
DNA
预后
卵巢肿瘤
Ovarian carcinoma DNA Image Prognosis
