摘要
本文报道了鼻咽癌(NPC)患者放射治疗前后全血硒(Se)和含硒酶—谷胱甘肽过过氧化物酶(Glutathione Peroxidase,GSH—PX)活性水平。研究结果表明,放射治疗前NPC患者全血硒含量与健康人相比无显著性差异(P>0.05);而放射治疗后NPC患者全血硒含量则较健康人低,两者间有显著性差异(P<0.05)。不同临床分期的NPC患者,放射治疗后全血硒含量随患者病情的加剧有下降的趋势。放射治疗前NPC患者全血GSH—PX活性较健康人低(P<0.01);放射治疗后NPC患者全血GSH—PX活性也较健康人低(P<0.01)。NPC放射治疗前不同临床分期各期患者全血GSH—PX活性均较健康对照组低(P<0.01);NPC放射治疗后不同临床分期各期患者全血GSH—PX活性也均较健康人低(P<0.01)。而且不管是放射治疗前还是放射治疗后NPCⅡ、Ⅲ和Ⅳ期各临床分期患者,其全血GSH—PX活性水平随患者病情从Ⅱ期向Ⅳ期的发展均有下降的趋势。
The blood samples colleted from 68 nasoparyngeal carcinoma(NPC) patients in stage 11, 111, IV before and at the end of radiotherapy and from46 healthy persons were analysed for selenium (Se) and glutatione peroxidase (GSH-PXActivities No significant difference in selenium level was found between the NPC patients before radiotherapy and control group (P>0.05). The selenium level in patients after radiotherapy was significantly lower than that in the normal control group (P P.05). The selen-iumlevel in NPC patients of different clinical stage after radiotherapy were lower than that in the control group. Furthermore, the selenium content of these patients decreased gradually with disease development However, the GSH-PX activities in NPC patients not only before radiotherapy, but also at the end of it were significantly lower than those of the normal control group(P<0.01). The enzyme activities in patients before and after radiotherapy of different clinical stages were lower than those of control group(F = 9.76P< 0.0001). In addition, it was found that the activities of GSH-PX in patients before and after radiotherapy decrease gradually with clinical stages of disease development. These suggested the determination of GSH-PX activities in NPC patients may be helpful in monitoring the clinical progression of the disease.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1993年第1期14-16,共3页
Chinese Journal of Cancer
基金
中山医科大学中青年科学基金
关键词
鼻咽肿瘤
谷胱甘肽
过氧化物酶
Nasopharyngeal carcinoma Radiotherapy Selenium Glutathions Peroxidase(G SH-PX)
