摘要
本文采用LCA—Aff—CIEA对94例原发性肝细胞癌(PHC)及66例非PHC(包括良性肝病45例、孕妇12例、其他病9例)进行AFP异质体(AFP—V)检测。以LCA结合峰面积>25％(AFP—R—L>25％)为阳性。两组血清AFP分别为21～17000μg/L及21～3300μg/L。结果表明AFP—V对PHC诊断的阳性率(敏感性)为96.8％,特异性84.8％,准确性91.9％。假阳性率达15.2％。本文阳性率及假阳性率及假阳性率均较明显地高于先前的报道。AFP对PHC的阳性率为72.3％,若结合AFP—V则可使阳性率提高至97.9％。我们也认为AFP—V的检测对PHC早期诊断和鉴别诊断确有重大意义。但由于假阳性率相对较高,特异性相对较低,其诊断价值可能受一定限制。本文还讨论了某些病例出现AFP—V假阳性的可能机理。
AFP Variant (AFP-V) was measured in 94 patients with pathological confirmed primary hepatocellular cancer (PHC) and 66 cases with non-PHC(included: 45 benign fiver diseases: 12 pregnant women: 9 other diseases), by using lens culinaris agglut: inin (LCA) affino-crossedimmuno-electrophoresis autoradiography (LCA-AFP-CIEA).Ser-un AFP ranged from21-17000ug / Land 21-3300 ug/L, respectively. The diagnostic criterion of AFP-V for PHC was AFP-R-L>25%.Our data showed that, in PHC, the ppstiverate (sensitivity), sepcificity and accuracy of AFP-V were 96.8% & 915%, respectively. The false positive rate was 15.2%. Both sensitivity and false positive rate were apparently higher than in previous reports. The positive rate of AFP for PHC was 72.3%. If AFP and AFP-V were determined simultaneously, the postive rate raised to 97.9%,it was higher than that previous reported AFP-V determination have important significance in the early and differential diagnosis of PHC, because more PHC would detected in early stage. However, relatively higher false positive rate and lower specificity of AFP-V for PHC appeared to limit its diagnostic value. The potential machanism of AFP-V false positive was discused.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1993年第1期17-19,共3页
Chinese Journal of Cancer
关键词
甲胎蛋白
放射免疫测定
肝细胞癌
Alpha-fetoprotein series Lens culinaris agglutinin(LCA) Radioimmunoassay Hepatocellular Carcinoma
