摘要
本实验分为体内体外两部分。体内实验证明芦笋对由肌氨酸乙酯亚硝胺诱发的小鼠前胃鳞状上皮癌变具有明显的抑制作用,对照组癌变率为63.0％,芦笋组为26.8％,两组癌变率与胃重比较在统计学上均有显著差异(P<0.01);形态学观察显示,芦笋不但可以降低癌变率而且可以阻止癌细胞的浸润。体外,芦笋对3T3细胞的生长曲线与分裂指数均有一定的抑制作用,细胞增殖缓慢,但无明显毒性。本文还讨论了芦笋抑制癌变的可能机理。
The experiment carried out in vivo and in vitro . In vivo, we demonstrated that Asparagus was able to inhibit the carcinogenesis of mouse forestomach induced by nitrososarcosine ethylester(NSEE). The incidence rate of carcinogenesis in control group and in Asparagus group was 63.0% and 26 .8% respectively. The difference between, two group was quite significant (p<0.01), Asparagus also prevented the invasion of carcinoma cell. In vitro, Asparagus inhibited the proliferation of 3T3 cells and its effect is not significant toxicity.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1993年第1期33-35,共3页
Chinese Journal of Cancer
关键词
芦笋
抗癌作用
3T3细胞
癌变
Asparagus Anticancer effect Mouse forestomach Squamous cell carcinoma NIH3T3 cell line
