摘要
为探讨男性吸烟和饮酒可能对下一代智力发育的影响,我们对淮北某煤矿225名男性职工及其妻子进行了回顾性定群研究。调查内容包括:225名男工在妻子怀孕以前3个月内的吸烟和饮酒习惯以及妻子怀孕期毒物接触史等19项目前已知的可能影响儿童智力发育的因素,并对调查对象的6—12周岁学龄期子女进行了智力测试。研究结果显示:6—12岁儿童的言语智商(VIQ)、操作智商(PIQ)、总智商(FIQ) 在父亲饮酒组和非饮酒组之间,以及父亲不同程度饮酒各组间均无明显差异(P>0.05)。男性吸烟对后代智力发育有明显影响。父亲吸烟组6—12岁儿童平均言语智商(83.97±17.05)、平均操作智商(81.93±15.45)和平均总智商(81.65±15.32)与非吸烟组6—12岁儿童平均言语智商(96.00±13.42)、平均操作智商(91.86±15.43)、平均总智商(94.02±12.63)之间有非常明显差异(P<0.01)。且吸烟程度越严重,其子女智商越低,呈明显剂量—效应关系。每天吸烟超过20支,其子女弱智(FIQ<70患病率为43.5％(20/46);而非吸烟组,弱智儿童仅4.8％(3/63);RR=9.06(P<0.01)。
Retrospective cohort study was made among 225 male coal miners and their wives to explore association of children' intelligence development and father's drinking and smoking during 3 months before their wives were pregnant. Smoking and drinking habits as well as 19 possible comfounding factors were investigated among 225 male coal miners and their wives, and intelligence quotients were tested among 225 school-age children ranging from 6 to 12 years old. Results show that all verbal intelligence quotient (VIQ), performance intelligence quotient(PIQ) and full intelligence quotient (FIQ) have not distinct differ- ence between the drinking group and the negative control (P>0.05). Average FIQs in all different groups determined by total amount of drinking during 3 months, average amount of drinking each time and average times weekly do not show abvious difference from that in negative control group. However, father's smoking seems to affect obviously children' intelligence development. There are evident differences in average VIQ. PIQ, FIQ between cigarette smoking group (VIQ:83.97; PIQ:81.93; FIQ:81.65) and nonsmoking group (VIQ:96.00; PIQ:91.86; FIQ94.02). Furthermore, the more fathers smoked, the lower children' average FIQs, and there is a distinct dose-effect relationship. The idot whose FIQ is below 70 amounts to 43.5% (20/46) in serious smoking grounp in which father smoked 20 or more cigarettes daily. Relative risk (RR) suffering from idiot in serious smoking group is 9.06 times as compared with 4.8% (3 / 63) in nonsmoking group.
出处
《癌变·畸变·突变》
CAS
CSCD
1993年第5期225-29,共1页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
吸烟
饮酒
智商
毒理学
cigarette smoking, alcohol drinking
full intelligence quotient (FIQ)
verbal in-telligence quotient (VIQ)
performance intelligence quotient (PIQ)
