摘要
本文报告了新维甲类化合物R8605对化学诱变剂环磷酰胺(CPA)和二甲基苯蒽(DMBA)引起微核形成的影响。结果表明:R8605(100mg/kgx4和50mg/kgx4,ig)可明显抑制CPA引起的小鼠骨髓嗜多染红细胞PCE和小鼠外周血淋巴细胞微核形成,已有DMBA引起的小鼠骨髓PCE微核形成,这说明R8605对化水诱变刻引起的染色体断裂有一定保护作用,具有抗诱变作用。
The effects of a new rctinoid R8605 on chemical mutagens cyclophosphamide (CPA) and 7,12-dimethylbcnz[a] anthracene (DMBA)-induced micronucleus formation were reported. The experimental results indicated that R 8605 (100mg/kg X 4 and 50mg/kg X 4, ig) singnificantly inhibited CPA-induced bone marrow and lymphocyte micronuclcus formation in mice, as well as DMBA-induced bone marrow micronucleus formation in mice, which suggest that R8605 exhibited a protective effect on chemical mutagens-induced chromsomal breakage, i.e. it have a anti-mutagenic action.
出处
《癌变·畸变·突变》
CAS
CSCD
1993年第5期34-37,共4页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
维甲类化合物
微核
抗癌药
R8605
rctinoids
micronuclcus formation
cyclophosphamide
7,12-dimethylbenz[a] anthraccne
anti-mutagenesis
