摘要
致癌性分类和分级是致癌危害性评定的主要步骤,对管理毒理学具有重要的意义。本文利用含47种化学品的致癌性数据库,比较了6种致癌性分类和评分方案。结果发现IARC分类和机理分类与致癌强度无显著的相关。TD50和多因素致癌性评分法具有某些局限性。对于遗传毒致癌物和非致癌物,多因素致癌性评分与遗传毒性联合评分有较好的相关(r=0.7872)。致癌性的综合评分方案应定量评价对人和动物的致癌性,还应考虑致癌作用机理、毒物动力学及生物学标志等研究资料。
Classification and ranking of carcinogens are main steps of hazard identification and have an important significance in regulatory toxicology. Six categorizing schemes for carcinogenic activity have been examined and applied to 47 chemicals in the present paper. The results indicated that IARC classification was based on sufficiency of evidence and was not relative to carcinogenic potency. The TD50 and multi-factor carcinogenicity ranking scheme had some limitations. A strong correlation was found between multi-factor carcinogenicity ranking values and combining genotoxicity score for genotoxic carcinogens and noncarcinogcns. The comprehensive ranking scheme for carcinogenic activity of chemicals should be a quantitive assessment of the animal and epidemiological data and consider the mechanistic, pharmacokinetic and biomarker study data.
出处
《癌变·畸变·突变》
CAS
CSCD
1993年第5期12-16,共5页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
致癌物
分类
致癌强度
肿瘤
carcinogen classfication
carcinogenic potency
hazard
