摘要
探讨了电离辐射诱发T淋巴细胞染色体畸变在新生儿与成年人之间的差异。采用在完全相同条件下用60Coγ射线一次照射离体的新生儿脐带血和成年人静脉血,新生儿照射0.5、1.0、2.0、3.0、4.0、5.0Gy;;成年人照射2.0Gy和3.0Gy,常规法分析染色体畸变率。结果表明,60Coγ射线照射2.0Gy和3.0Gy诱发新生儿T淋巴细胞染色体着丝粒畸变率相当于成年人的130%左右,无着丝粒畸变率两者几乎相同。60Coγ射线诱发新生儿T淋巴细胞染色体着丝粒畸变率符合线性2次多项式y=4.8104D2+5.8314D+0.0034模式,r=0.9982。初步结果表明,新生儿T淋巴细胞对电离辐射的敏感性显著高于成年人。
To compare the sensitivity of chromosome aberrations induced by ionizing radiation between newborns and adults, Cord bloods from newborns and peripheral blood from adults were exposed to 60Co γ?rays under same condition, and then the chromosome aberrations were analyzed by using conventional method. Results: Dicentric frequency in lymphocytes of newborns induced with 2.0Gy and 3.0Gy is about 130% more than those of adults. And the frequencies of acentric aberrations between newborns and adults are almost same; The frequencies of dicentric in lymphocytes from newborns induced by Co γ?rays fits linear-quadratic dose-response equation which is 60 described by the formula, y =4.8104D2+5.8314D+0.0034 (r =0.9982). Sensitivity of newborn to ionizing radiation is significantly higher than that of adult.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
北大核心
2004年第3期185-188,共4页
Journal of Radiation Research and Radiation Processing
关键词
辐射敏感性
染色体畸变
新生儿
成年人
淋巴细胞
Radiation Sensitivity, Chromosome aberrations, Newborns, Adults, Lymphocytes
