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多丙烯酰胺水凝胶的细胞毒性 被引量:1

Cytotoxicity of polyarylamide hydrogel
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摘要 本文的目标是要确定从PAM水凝胶提取的丙烯酰胺的容量,并测定提出物的细胞毒性。本文所用的材料是由乌克兰InterfallCo.生产的Gel-Interfall(Lot:030103)。为了测定丙烯酰胺的单体应用了HPLC,并且在单体细胞毒性的计算中包含了MTT的检定。结果表明:在细胞毒性和材料的单体丙烯酰胺容量之间存在着某些关系。 The aim of this paper was to determine the acrylamide content in the extracts from PAM hydrogel, and examine the extracts cytotoxicity. The materials used in this paper were Gel-Interfall(Lot: 030103) manufactured by Interfall Co. Ukraine. HPLC was used for detection of acrylamide monomer, and MTT assay was involved in the evaluation of the monomer cytotoxicity. The results indicated that it has some correlation between the cytotoxicity and the monomer acrylamide content of the materials.
出处 《大连大学学报》 2004年第2期20-21,24,共3页 Journal of Dalian University
基金 supported by 863 Program(2002AA326040).
关键词 PAM 丙烯酰胺 水凝胶 细胞毒性 HPLC cytotoxicity, PAM, acrylamide
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参考文献3

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  • 2YANG M, DING Y, ZHANG L, et al. Novel thermosensitive polymeric micelles for docetaxel delivery[ J]. J Biomed Mater Res A, 2007, 81 (4) :847-857.
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