摘要
为探讨纳洛酮预处理大鼠后对其肝细胞缺血再灌注损伤的影响 ,短期对 Wistar大鼠腹腔内注射纳洛酮 ,然后制作缺血再灌注损伤模型 ,检测血清中谷丙转氨酶 (ALT)和谷草转氨酶 (AST)的含量 ,检测肝组织中丙二醛 (MDA)和超氧化物歧化酶(SOD)的含量 ,通过光镜、电镜观察 ,了解肝细胞形态学及超微结构的改变。结果显示 ,纳络酮预处理组血清中 AL T和 AST含量及肝组织中 MDA含量于缺血再灌注组 (P<0 .0 5 ) ,而肝组织中 SOD含量则高于缺血再灌注组 (P<0 .0 5 ) ,与假手术组无明显差异 。
To investigate the effect of preconditioning of naloxon on hepatocyte after ischemia\|reperfusion in rat. Naloxon was intraperitonealy injected, and the models of ischemia\|reperfusion was made. The content of ALT and AST in serum and the content of MDA and SOD in liver tissue were measured. The morphological and ultrastructural observation of hepatocyte was examined through light microscope and electron microscope. The content of ALT and AST in serum and the content of MDA and SOD in liver tissue of the preconditioning of naloxon group were lower than that of the ischemia\|reperfusion group significantly ( P< 0.05) . The content of SOD in liver tissue of the preconditioning of naloxon group was higher than that of the ischemia\|reperfusion group significantly ( P<0.05) . There were no significant differences between that of the preconditioning of naloxon group and the pseudooperation. The abnormal changes of the morphology of hepatocyte were reduced remarkably.
出处
《数理医药学杂志》
2004年第3期262-265,共4页
Journal of Mathematical Medicine
