摘要
目的 检测血管性假血友病因子、可溶性细胞间黏附分子 1浓度变化 ,以研究其在ARDS早期诊断中的意义。方法 以ELISA法检测非ARDS组和ARDS组于 0、 2、 3、 5和 7d血浆vWF和sICAM 1浓度。结果 ARDS组vWF和sICAM 1浓度高于非ARDS组 ,前四个时点的中性粒细胞活化计数ARDS组高于非ARDS组。血浆vWF和sICAM 1水平具有相关性。结论 血浆vWF和sICAM 1浓度及中性粒细胞活化计数在ARDS的早期即升高 ,对ARDS早期诊断有预警作用。
Objective To measure the plasma levels of vWF and sICAM-1 in patients at risk for the development of ARDS,and to evaluate their significance in early diagnosis of ARDS.Methods Plasma vWF and sICAM-1 were both measured with ELISA in patients without ARDS group and with ARDS group on admission and at day 2,3,5,7. Results A statistically significant difference was found in the mean vWF level for ARDS and non-ARDS patients at the first three time points. And the sICAM-1 levels between the two groups at the first four time points also showed a statistical significant difference.The counts of activated neutrophil at the first four time points of ARDS group were significantly greaterthan those in non-ARDS group. There was a positive correlation between plasma levels of vWF and sICAM-1.Conclusion Plasma levels of vWF and slCAM-1 and the counts of activated neutrophil were elevated in early ARDS. These observations suggest that there are injury of endothelium andneutrophil activation in early ARDS.
出处
《中华急诊医学杂志》
CAS
CSCD
2004年第4期251-253,共3页
Chinese Journal of Emergency Medicine
