摘要
人们对控制胆固醇吸收和血浆植物甾醇水平的分子基础了解尚少 .ABCG5和ABCG8的发现使得理解甾醇吸收的分子基础获得突破 .ABCG5和ABCG8主要涉及植物甾醇代谢 ,而其他基因涉及胆固醇吸收 .最近 ,一种新胆固醇吸收阻止剂 (ezetimibe)的问世 ,给胆固醇吸收和血浆植物甾醇水平基因控制研究提供新的亮点 .主要综述胆固醇吸收和血浆植物甾醇水平的基因控制 ,关注调节它们的共同点和不同点 。
The molecular basis of the processes of cholesterol absorption and plasma plant sterol levels is only partially understood. A breakthrough in understanding the molecular basis of sterol absorption has recently achieved by the discovery of AFCG5 and ABCG8. The genes involved in cholesterol absorption and plant sterols metabolism are characterized by a spectrum of specificity. Studies on a recently developed novel cholesterol absorption-blocking agent, ezetimibe, provide additional insight into the genetics of cholesterol absorption and plasma plant sterol levels. Focuses on the evidence for genetic control of cholesterol absorption and plasma plant sterol levels are reviewed. The commonalities and difference in the regulation of these two traits are examined and the recent developments and future perspectives in this field are discussed.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2004年第5期398-401,共4页
Progress In Biochemistry and Biophysics
基金
湖南省科技厅重点资助项目 ( 0 1SSY10 0 3 )
湖南省卫生厅资助课题 (Y0 2 0 65 )
湖南省教育厅资助课题 ( 0 2C3 99)~~
