摘要
观察T2N2M0期鼻咽癌同步放、化疗的疗效及不良反应,探讨该方法的可行性。方法:70例T2N2M0期鼻咽癌患者,随机分为同步放、化疗组(A组)和单纯放疗组(B组)。两组放疗方法、时间、剂量分割均相同,A组分别于放疗的第1、4和第7周同时给予顺铂(DDP)+5-氟脲嘧啶(5-FU)化疗。结果:放疗剂量至40Gy时,A组鼻咽病灶及颈淋巴结CR+PR率分别为74.29%(26/35)和94.29%(33/35),明显高于B组的65.71%(23/35)和77.14%(27/35),P<0.05;5年生存率A组为68.57%(24/35),B组仅40.00%(14/35),有显著差异(P<0.05);远处转移发生率B组较A组高(P<0.01);A组口腔粘膜及白细胞计数的Ⅱ、Ⅲ级不良反应较B组明显。结论:同步放、化疗可明显提高T2N2M0期鼻咽癌的5年生存率及减少远处转移,而白细胞计数及口腔粘膜等不良反应较明显,但大部分患者仍可以接受。
Objective: To study the therapeutic efficacy and toxic side effects of radiotherapy with synchronous chemotherapy on stage T2N2M0 nasopharyngeal carcinoma, thus to investigate its feasibility.Methods: 70 cases of stage T2N2M0 nasopharyngeal carcinoma were randomly assigned to group A which was subjected to combined radiotherapy and chemotherapy and group B which was subjected to radiotherapy simply. The methods, times and dose schedule of radiotherapy were similar in the two groups. Patients in the combined treatment group were subjected to chemotherapy of cis-dichlorodiamine platinum(DDP) and 5-Fliorouracil (5-FU) at the 1st, 4th and 7th week after radiotherapy. All the patients underwent the treatment as planned. Results: When the dose of radiotherapy was 40GY, the CR+PR rate of nasopharyngeal foci and cervical limph nodes in group A were 74.29%(26/35)and 94.29%(33/35) respectively and were significantly higher than that of group B in which the values were 65.71%(23/35) and 77.14%(27/35) respectively. The 5-year survival rate of group A was 68.57%(24/35),while that of group B was merely 40.00%(14/35)and the differences between the two groups were statistically significant (?字2=5.7 P<0.05). The distant metastasis occurrence rate of group B was higher than that of group A (?字2=16.80 P<0.01). Ⅱ?Ⅲ stage acute toxic side effects of oral mucosa and numeration of leukocyte of group A was more significant than that of group B. Furthermore about one third of patients in group A, Conclusion: Combined radiotherapy and chemotherapy can significantly increase 5-year survival rates and decrease distant metastasis of stage T2N2M0 nasopharyngeal carcinoma. Although the resultant acute toxic effects were not decreased, most patient can endure.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2004年第10期578-580,共3页
Chinese Journal of Clinical Oncology
关键词
鼻咽肿瘤
化学疗法
放射疗法
Nasopharyngeal neoplasm Chemotherapy Radiotherapy
