摘要
目的 探讨尿石症患者的发病年龄、发病诱因及发病季节等因素与家族史的关系。 方法 采用问卷调查形式对 36 0例有家族史和 12 0 0例无家族史尿石症患者及 10 0 0例正常对照组进行调查。 结果 ① 36 0例有家族史尿石症者中 ,一级亲属和二级亲属的患病率分别为 10 .71% (14 7/1372 )、1.6 8% (5 4 / 32 14 ) ;而对照组一级亲属和二级亲属的患病率分别为 0 .6 6 % (2 3/ 3480 )、0 .12 % (9/7345 )。②有家族史尿石症者中 ,男性平均发病年龄 (2 6 .35岁 ) ,女性 (36 .4岁 ) ,两组比较差异有显著性意义 (t=1.75 ,P <0 .0 5 )。有家族史男性发病年龄 (2 6 .35岁 )早于无家族史男性 (2 9.31岁 ,t =2 .2 15 ,P <0 .0 5 ) ,女性患者有家族史者平均发病年龄 34.9岁 ,无家族史者平均发病年龄 35 .2岁 ,二者比较差异无显著性意义 (t=0 .739,P >0 .0 5 )。③发病诱因、发病季节在有家族史和无家族史间无统计学意义 ,但环境因素两组比较差异均有显著性意义 (χ2 =0 .2 3,P <0 .0 5 )。 结论 尿石症是一种多因素的且可能与遗传因素有关的疾病。
Objective To investigate the association of age,precipitating factors and seasons of symptom onset of urinary stones with patients who have or have no family history. Methods The questionaires were used to survey 360 urinary stone cases with family history,1200 cases without family history and 1000 normal controls in Chongqing Area. Results In the 360 patients with family history,the morbidity rates of the first degree relatives and second degree relatives were 10.71%(147/1372) and 1.68%(54/3214), respectively.But in those without family history,the morbidity rates of the first degree relatives and second degree relatives was 0.66%(23/3480) and 0.12%(9/7345),respectively.Among the patients with family history,the mean age of morbidity for the males (26.35 years) was younger than that of the females (36.4 years, t=1.75,P <0.05).Male with family history(26.35 years) had symptom onset earlier than those without family history(29.31 years t=2.215,P <0.05) ,while in female there was no significant difference of onset age between the 2 groups (34.9 vs 35.2 years, t=0.739,P >0.05).There was no significant difference of the precipitating factors and symptom onset seasons between patients with or without family history,while the enviropmental factors had significant effects on the morbidity of urinary stone patients,without regard to family history(χ 2=0.23, P <0.05). Conclusions The genetic factor plays an important roles in the morbidity of urinary calculus patients with family history.Urinary calculus is a multi-factor and genetic associated disease.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2004年第5期345-347,共3页
Chinese Journal of Urology
