摘要
目的 了解视觉反馈对幼猴正视化过程的调控作用。方法 年龄 2～ 3个月的健康恒河猴 8只 ,每只猴一只眼接受准分子激光角膜屈光手术 (PRK) ,使术后产生 3 0 0D相对近视或远视性离焦 (各 4只 ) ;另一只眼作为对照。术后不同时间用角膜地形图、散瞳验光、A超和裂隙灯显微镜动态观察猴眼的变化。结果 术眼角膜上皮均在术后 3d之内完全愈合 ,在观察期内角膜保持透明。实验眼均表现为代偿生长的过程 ,玻璃体腔增长速率随术后屈光状态不同而变化。术后远视性离焦 ,玻璃体腔增长速率较对照眼快 (t=3 6 5 6 ,P =0 0 35 4 ) ;术后近视性离焦 ,玻璃体腔增长速率较对照眼慢 (t=3 5 76 ,P =0 0 374 )。结论 PRK造成光学离焦 ,可以调控幼猴的玻璃体腔生长和正视化过程 ,表明幼猴的正视化过程受视觉反馈的调节 ,提示临床上婴幼儿屈光不正的光学矫正应慎重。PRK造成猴眼光学离焦动物模型可用于视觉科学的研究。
Objective To investigate the effect of photorefractive keratectomy (PRK) induced defocus on emmetropization in infant rhesus monkeys and to determine the role of visual feedback on emmetropization.Methods PRK was performed in 8 healthy rhesus monkeys age ranging from 2 to 3 months. Either 3.00 D of relative hyperopic or myopic defocus was produced in one eye and the fellow eye as controls. The eyes were examined periodically with corneal topography,cycloplegic retinoscopy,A-scan ultrasonography,and slit-lamp biomicroscopy. Results All operated eyes demonstrated re-epithelialization within 3 days post-surgically and maintained transparent. Compensating axial length growth occurred throughout the observation period. The rate of vitreous chamber elongation varied with the post-PRK refractive status of the eye. The hyperopia-induced eyes exhibited a vitreous chamber elongation faster than the fellow eyes ( t =3.656, P =0.0354),whereas myopia-induced eyes demonstrated a vitreous chamber elongation slower than the fellow eyes ( t =3.576, P =0.0374). Conclusions PRK-induced-defocus altered axial growth rates and emmetropization in infant monkeys predictably. These results indicate that primate emmetropization is regulated by visual feedback and correction of refractive error on children should be careful. PRK-induced-defocus is a promising method for myopic animal model and for the investigation of vision science. (China J Ophthalmol,2004:40:258-261)
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2004年第4期258-261,共4页
Chinese Journal of Ophthalmology
基金
国家自然科学基金资助项目 (3 0 10 0 2 0 5
3 0 1710 0 1)
