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肾上腺髓质素对肝硬化大鼠门静脉压力的影响 被引量：3

Effect of adrenomedullin on portal vein pressure of cirrhotic rat.
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摘要 肾上腺髓质素(ADM)是新近发现的一种具有强大扩血管作用的血管活性物质,在体内分布广泛[1].肝硬化患者血浆ADM浓度明显升高[2].
作者 邓存良 陈文 王明勇 陈枫 赵春林 冯志强
机构地区 泸州医学院附属医院感染科 泸州医学院生理学教研室
出处 《中华肝脏病杂志》 CAS CSCD 2004年第3期177-178,共2页 Chinese Journal of Hepatology
关键词 肾上腺髓质素 肝硬化 大鼠 门静脉压力 血管活性物质 Hypertension, portal Liver cirrhosis Rat Adrenomedulli
分类号 R575.2 [医药卫生—消化系统]
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参考文献4

  • 1Kitamura K, Kangawa K, Kawamoto M, et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma.Biochem Biophys Res Commun, 1993, 192: 553-560.
  • 2Fernandez-Rodriguez CM, Prada IR, Prieto J, et al. Circulation adrenomedullin in cirrhosis: relationship to hyperdynamic circulation.J Hepatol, 1998, 29: 250-256.
  • 3Gorbig MN, Gines P, Bataller R, et al. Human hepatic stellate cells secrete adrenomedullin: potential autocrine factor in the regulation cell contractility. J Hepatol, 2001, 34: 222-229.
  • 4Hattori Y, Nakanichi N, Gross SS, et al. Adrenomedullin augments nitric oxide and tetrahydrobioptein synthesis in cytokine-stimulated vascular smooth muscle cells. Cardiovasc Res, 1999, 44: 207-214.

同被引文献21

  • 1KITAMURA K, KANGAWA K, KAWAMOTO M, et al. Ad- renomedullin: a novel hypotengive peptide isolated from human pheochromocytoma[J]. Biochem Biophys Res Commun, 1993, 192(2) : 553 -560.
  • 2KOJIMA H, TSUJIMOTO T, UEMURA M, et al. Significance of increased plasma adrenomedullin concentration in patients with cirrhosis[J]. J Hepatol, 1998, 28(5) : 840 -846.
  • 3LI X, BENJIMIN I S, ALEXANDER B. Reproducible production of thioacetamide - induced macronodular cirrhosis in the rat with no mortality[J]. J Hepatol, 2002, 36(4) : 488 -493.
  • 4JOUGASAKI M, BURNETY J C Jr. Adrenomedullin: potential in tCnysiology and pathophysiology [ J ]. Life Sci, 2000, 66 ( 10 ) : 855 - 872.
  • 5ROCKEY D C, WEISIGER R A. Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance [ J ]. Hepatology, 1996, 24(1): 233-240.
  • 6BATALLER R, NICOLAS J M, GINEES P, et al. Contraction of human hepatic stellate cells activated in culture: a role for voltage -op- erated calcium channels[J]. J Hepatol, 1998, 29(3) : 398 -408.
  • 7ROCKEY D. The cellular pathogenesis of portal hypertension: stellate cell contractility, endothelin, and nitric oxide [ J ]. Hepatology, 1997, 25(l) : 2-5.
  • 8KAWADA N, INOUE M. Effect of adrenomedullin on hepatic perycites (stellate cells) of the rat[J]. FEBS Lett, 1994, 356 (1): 109-113.
  • 9GORBIG M N, GINES P, BATALLER R, et al. Human hepatic stellate cells secrete adrenomedullin: potential autocrine factor in the regulation of cell contractility [ J ]. J Hepatol, 2001, 34 ( 2 ) : 222 - 229.
  • 10TSURUDA T, KATO J, HATAKEYAMA K, et al. Antifibrotic effect of adrenomedullin on coronary adventitia in angiotensin Ⅱ - induced hypertensive rats [ J ]. Cardiovasc Res, 2005, 65 (4) : 921 - 929.

引证文献3

二级引证文献4

中华肝脏病杂志
2004年 第3期

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