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糖尿病肾病及其候选基因 被引量：3

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摘要 糖尿病肾病 (DN)是糖尿病 (DM)常见的微血管并发症之一 ,大量证据表明遗传因素在DN发生发展中起重要作用 ,其发病与基因多态性、基因突变及异常表达等有关 ,本文就目前研究发现的与糖尿病肾病有关的基因作一综述。其主要包括肾素血管紧张素系统的基因如 :血管紧张素Ⅱ 1型受体基因 ;参与非胰岛素依赖的糖代谢相关的基因如 :醛糖还原酶基因、葡萄糖转运蛋白基因 ;与蛋白质代谢相关基因如 :亚甲基四氢叶酸还原酶基因 ;与脂质代谢有关的基因如 :载脂蛋白E基因以及其它相关基因。研究结论不尽一致 ,利用基因芯片等高通量研究手段为深入研究与糖尿病肾病发生发展密切相关的基因提供了有利工具。
作者 谢祥成 原爱红
机构地区 不详 上海同济大学附属同济医院肾内科
出处 《国外医学（泌尿系统分册）》 2004年第3期391-394,共4页 Foreign Medical Sciences(Urology and Nephrology Foreign Medical Sciences)
关键词 糖尿病肾病 基因
分类号 R692.9 [医药卫生—泌尿科学]
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参考文献21

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二级参考文献3

共引文献17

同被引文献31

  • 1Okada S, Shikata K, et al. Intercellular adhesion molecule-1-deficient mice are resistant against renal injury after induction of diabetes[J]. Diabetes, 2003 Oct,52(10) :2586.
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  • 6Anjaneyulu M, Chopra K. Effect of Irbesartan on the Antioxidant Defence System and Nitric Oxide Release in Diabetic Rat Kidney[J]. Am J Nephrol, 2004 Sep 7,24(5) :488.
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引证文献3

二级引证文献12

国外医学（泌尿系统分册）
2004年 第3期

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