摘要
4组大鼠分别喂以玉米面为主组成单一的偏食或常规食。两个月后间隔16h注射速尿两次。偏食组有明显反应,再注射NaNO_2或异丙基肾上腺素(ISP),发生严重心肌坏死,坏死程度显著重于常规食组(P<0.01)。这一动物模型有利于说明膳食因素对克山病心肌坏死的影响及进一步研究克山病心肌坏死的发生机理。
Four groups of rats kept on a monotonous diet mainly consisting of corn or on a stock diet separately for two months. Intraperitoneal injection of furosemide was performed twice at an interval of 16 hours. Rats in the monotonous diet groups showed a serious reaction to the furosemide injected and presented severe myocardial necrosis after repeated injections of NaNO2 or isoproteroneal. The myocardial necrotic areas in the monotonous diet groups were significantly larger than those of the stock diet groups (P<0. 01). This animal model will contribute to explanation of the effect of dietary, factors on myocardial necrosis in Keshan disease and to the further reseach on the mechanism of myocardial necrosis in Keshan disease.
出处
《白求恩医科大学学报》
CSCD
1992年第3期217-219,F004,共4页
Journal of Norman Bethune University of Medical Science
关键词
克山病
心肌坏死
膳食因素
速尿
Keshan disease Myocardial necrosis Dietary factors Furosemide
