摘要
目的 :观察地尔硫治疗急性冠状动脉综合征的剂量及临床疗效。方法 :2 5例急性冠状动脉综合征患者静脉滴注地尔硫 1～ 5 μg·kg-1·min-1,持续用药 4 8h。结果 :ST段抬高型心绞痛及非ST段抬高型心绞痛用药前后心绞痛发作次数明显减少 (P <0 .0 5 ) ;地尔硫治疗ST段抬高型心绞痛较非ST段抬高型心绞痛更为有效 (P <0 .0 5 )。地尔硫可不同程度地降低心率、血压及心肌氧耗量 ,其中用药后 2h及 12h心肌氧耗量明显下降 (P <0 .0 5 )。结论 :静脉滴注地尔硫 1～ 3μg·kg-1·min-1可有效改善各种类型心绞痛的发作 ,且其不良反应小。
Objective:To observe the efficacy of continuous intravenous infusion of diltiazem on patients with acute coronary syndrome. Method: Twenty-five patients with acute coronary syndrome received continuous intravenous diltiazem 1～5 μg·kg -1·min -1 for 48 h. Result: With the therapy of diltiazem, the symptom of ST elevated angina pectoris and non ST elevated angina pectoris were significantly improved. During the treatment, diltiazem decreased heart rate, blood pressure and oxygen consumption of myocardium. Oxygen consumption of myocardium decreased significantly in 2 and 12 h after infusion of diltiazem(P< 0.05). Diltiazem was more effective on ST elevated angina than on non ST elevated angina(P< 0.05). Conclusion: Continuous intravenous infusion of diltiazem 1～3 μg·kg -1·min -1 is an efficient and safe therapy for patients with acute coronary syndrome.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2004年第5期285-286,共2页
Journal of Clinical Cardiology
