摘要
目的 应用磁共振扩散张量成像技术 (diffusion tensor im aging DTI),对阿尔茨海默病 (Alzheimer'sdisease AD )患者顶叶及胼胝体膝部脑白质损伤的情况与临床认知评价之间的关系进行初步研究。方法 对 22例AD 患者和 22例健康老年人进行脑部 DTI 扫描后,测量顶叶和胼胝体膝部的各向异性分数值 (fractional anisotropyFA ),应用成组 t检验对 AD 组和正常对照组的相应区域进行比较,并用部分相关性检验对 AD 患者脑中各部位相应取值与临床认知评价量表之间的关系进行统计。结果 AD 患者左侧顶叶 FA 值与记忆相关量表评分呈正相关。胼胝体膝部 FA 值与 M M SE 评分呈正相关。结论 DTI 技术能够在一定程度上反映 AD 患者脑白质受损情况与认知功能缺损的关系。
Objective To determine the relationship between the extent of the damage and clinical data in Alzheimer′s disease(AD). Methods Twenty-two patients with AD and twenty-two controls received MR-diffusion tensor scanning. The fractional anisotropy(FA)values of white matter in AD patients were measured respectively in parietal lobe and the genu of corpus callosum. Independent-samples t-test for non-paired data was used to test differences between AD and controls for FA values. Correlation analysis was applied to reveal the correlations between FA values in each region and the MMSE, FOM, RVR, BD and DS scores. Results Positive correlations were found between FA values in left parietal lobe and FOM/DS, and between FA values in genu of corpus callosum and MMSE scores. Conclusions In AD, the MR-DTI can reflect the relationship between the degree of white matter abnormalities and the cognitive impairment.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2004年第2期134-138,共5页
Acta Academiae Medicinae Sinicae
关键词
阿尔茨海默病
磁共振扩散张量成像
认知评价
各向异性分数
Alzheimer′s disease
diffusion tensor imaging
clinical cognitive evaluation
fractional anisotropy
