摘要
观察了5名正常月经周期妇女(正常组)及19例多囊卵巢综合征患者(根据电针后有无排卵分为排卵组及无排卵组)血内 LH、PRL 在月经第4天时对多巴胺受体阻断剂美托氯普胺(metoclo-pramide,MCP)及第12天时对阿片肽受体阻断剂纳络酮(naloxone,NAL)的反应。发现血 LH、PRL 在月经第4天时对 MCP 的反应两者间无明显差异。正常组月经第12天时血 E_2水平较高,4小时静脉滴注NAL 后2小时血 LH 仍维持在较高水平(P<0.01);排卵组血 E_2有一定水平,滴注 NAL 后血 LH 显著升高(P<0.05),但程度上没有正常组明显;无排卵组血 E_2水平较低,滴注 NAL 后血 LH 升高不显著(P>0.05)。滴注 NAL 后正常组血 PRL 显著升高(P<0.01),而患者则无明显升高。结果提示本实验多囊卵巢综合征患者中枢阿片肽活动力偏低而中枢多巴胺活动力无特殊异常现象,推测多囊卵巢综合征患者电针促排卵可能与中枢多巴胺活动力关系不大,而是通过调节中枢阿片肽活动力起作用的。作者发现中枢阿片肽活动力的高低和体内雌激素水平存在正向关系,临床可以雌激素水平在滤泡期的变化作为中枢阿片肽活动力的观察指标之一。
Responses of LH and PRL to metoclopramide
(MCP,the dopamine receptor antagonist) on the 4th
cycle day and to naloxone(NAL,the opioid recepter
antagonist) on the 12th cycle day were observed in 5
women with normal menstrual cycles and 19 patients
with polycystic ovary syndrome(PCOS),who were
subdivided into ovulatory(7 cases) and anovulatory
(12 cases) after ovulatory induction with electric-
acupuncture(EA).In the MCP test,there were no
significant differences between the normal and PCOS
patients(P>0.05).in the NAL test,serum LH lev- els were significantly elevated in the normal group(P<
0.01) and less elevated in the PCOS with ovulation af-
ter EA,but not elevated in anovulatory PCOS(P<
0.05).Response seemed to be related with E:levels.
Serum E:levels were significantly higher in the normal
(P<0.001) and lower in the ovulatory PCOS and even
lower in the anovulatory PCOS(P<0.1≈0.05).In
summary,the opioid activity of CNS was lower in
PCOS patients than in the normal women,while the
EA activity of CNS is similar in both groups.Effect of
ovulation with EA seemed to be regulated through opi-
old activity.Serum E:level might be a sign for EA
treatment.
出处
《生殖医学杂志》
CAS
1992年第1期16-19,共4页
Journal of Reproductive Medicine
关键词
多囊卵巢综合征
内啡肽类
电针
针刺疗法
促排卵
Polycystic ovary syndrome Acupuncture
Endorphins
Dopamine Naloxone
Metoclopramide
