摘要
作者取同龄健康的Wistar乳鼠,随机分成克汀病组和对照组。喂养三个月后,两组体重、甲状腺素(T_4)、促甲状腺激素(TSH)均有显著差异。测定血清中总羟脯氨酸(HYP)的含量,克汀病组为0.15mmol/L,对照组为0.247mol/L,P<0.001,说明汀病大鼠体内胶原代谢缓慢,骨骼发育迟缓,所以血清HYP含量不仅可以作为胶原蛋白代谢和含量的指标,也可作为甲状腺功能检测的重要生化指标。硒是人和动物的必需微量元素。如果硒缺乏有关的代谢过程就会由于缺硒而阻断,可能导致多种疾病。作者所测克汀病大鼠血硒水平明显低于对照组(P<0.05),提示硒缺乏可能是致克汀病发生的因素之一。
The author took the healthy wistar neonatal rats of the same age, then divided them at rondom into the cretin group and the control group. After feeding, for three month the body weight and the serum T_3、T_4 between the two groups were siginificantly different. The content of the whole serum hydxoxyproline (hyp), was 0.150mmol/L in the certin group and 0. 247mmol/L P<0. 001 in the. control The result demostrated that the collagen metabolism in cretin rat bodies was slow, and the bone marrow growth was also slow. Thus, the content of the serum hyp not only could serye as an index of the collagen metabolism, but also could serve as an important biochemical index to measure the function of thyroid.
The element Se is an essential micrroelement to the human kind and animals. If Se is short, the metabolic processes concerned may be inhibited because of the deficiency of Se, which can lead, to many diseases. The blood Se level of the cretin rats the author measured was siginificantly lower than that of the control group, which suggested that Se deficiency might be one of the. factors leading to cretin.
出处
《锦州医学院学报》
1992年第5期4-6,共3页
Journal of Jinzhou Medical College
