摘要
以G_(s-2)、P_(s-7)、P_(s-10)三株单克隆抗体用SABC-ELISA结合抑制法检测胃液中的胃癌相关抗原,以结合抑制率间接反应抗原含量。结果表明三株单抗对应抗原在胃癌患者胃液中的平均含量明显高于正常对照及非癌胃部疾病患者(P<0.001)。其阳性率分别为71.4％、65.O％、74.6％。比较同一病例中胃液抗原含量与胃癌组织的抗原表达,发现两者基本一致。三株单抗组合应用,胃癌阳性率达92.0％。正常对照组阳性率为12.0％,具有较高的临床诊断价值。
Three monoclonal antibodies (McAbs): Gs-2, Ps-7 and Ps-10 were used to detect cancer associated antigen in gastric juice in patients with gastric cancer by biding inhibition SABC-ELISA method compared with antigen expres-sion in gastric cancer tissue simultanously. the mean inhibition rate are significantly higher in patients with gastric cancer than that of benign lesions or normal control (P<0.001). the postive rates of gastric cancer were 71.4%> 65.0%, 74.6% respectively. combination of three McAbs (cocktail) showed a higher positive rate in gastric cancer (92.0%), whereas in 'control' group, it remained low (12.0%). the resnlts provide a useful tool in the diagnosis of gastric cancer.
出处
《军医进修学院学报》
CAS
1992年第4期334-336,共3页
Academic Journal of Pla Postgraduate Medical School
关键词
胃肿瘤
诊断
免疫学
肿瘤抗原
胃液
Stomach neoplasms Diagnosis Immunology Neoplasm antigen Gastric juice Analysis
