摘要
用^(131)I-三甲基羟基-间碘-苯二胺(^(131)I-HIPDM)静脉注入动物体内,发现肺脏有很高的摄取。并对14例健康自愿者,17例慢性阻塞性肺气肿及5例支气管哮喘患者肺廓清^(131)I-HIPDM功能进行研究。发现^(131)I-HIPDM肺显像一定程度上反映肺血管内皮细胞或受体分布状态。分析肺廓清^(131)I-HIPDM动态曲线可形成一个新的肺功能障碍指数。
After the rats were injected with ^(131)I-HIPDM by vein, much was taken by the lung. 14 normal individuals, 17 cases of chronic obstructive pulmonary emphysema, 5 cases of asthma were studied. The results showed that the metabolism and development of ^(131)I-HIPDM in the lung may reflect on condition of the pulmonary endothelial cells or receptors. The clearance curve of ^(131)I-HIPDM was slow in the patients with chronic obstructive pulmonary mphysema, especially the patients of smokers. The analysis of the lung clearance of ^(131)I-HIPDM forms a new index of lung dysfunction.
出处
《军医进修学院学报》
CAS
1992年第3期221-224,共4页
Academic Journal of Pla Postgraduate Medical School
关键词
肺疾病
阻塞性肺疾病
代谢廓清率
诊断
苯二胺类
Lung diseases
obstructive
Radionuclide imaging
Metabolic clearance rate
Diagnostic use
Phenylenediamines
