摘要
本文报告用Sandostatin治疗5例活动性肢大症。疗程6个月。Sandostatin剂量450～1500μg/日,分次皮下注射。治疗后头痛、软组织肿胀等症状明显减轻。4例患者血清平均GH水平下降50％以上,1例无下降。4例垂体瘤体积稍缩小。1例糖尿病好转,1例出现糖耐量异常。另1例出现胆囊结石,停药一年后随诊,胆结石消失。结果提示Sandostatin能有效地降低血清GH水平,改善临床症状。对药物的副作用应作进一步观察。
Five patients with active acromegaly were treated with Sandostatin for 6 months. The dosage of Sandostatin was 450 to 1500ug daily and it was injected subcutaneouly in divided dose every 8 hours. After treatment the symptoms of headche and soft tissue swelling were improved. The mean serum GH level was reduced by more than 50% in 4 patients and remained unchanged in (?). Slight shrinkage of pituitary GH-secreting tumor was found in 4 patients. Diabetes was improved in 1 patients, while glucose intolerance occurred in 1 case. One patient developed gallbladder stone during treatment, but it disappeared spontaneously 1 year after withdrawing Sandostatin. The authors suggested that sandostatin might be effective in reduction of serum GH, but the side effects of the drug should study further.
出处
《军医进修学院学报》
CAS
1992年第3期196-199,共4页
Academic Journal of Pla Postgraduate Medical School
