摘要
目的 探讨本院 5年中黄杆菌属医院感染的分布及其耐药现况。方法 黄杆菌属的分离和鉴定用全自动微生物分析系统 VITEK- AMS6 0及配套革兰阴性杆菌鉴定卡 (GIN)和药敏卡 (GNS)。结果 发现感染者多为脑外科、ICU和呼吸科病房患者 ;均有吸氧、吸痰史 ,有行气管插管、机械通气史 ,对亚胺培南 >95 %耐药 ,头孢噻肟、头孢曲松、氨曲南、庆大霉素、阿米卡星各 >90 %耐药 ,对头孢哌酮 /舒巴坦、环丙沙星、左氧氟沙星、复方新诺明、哌拉西林、哌拉西林 /他唑巴坦耐药率均 <6 0 %。结论 黄杆菌属医院感染有逐年增多趋势 ,且对多种抗生素耐药性高 ,头孢哌酮 /舒巴坦、哌拉西林 /他唑巴坦是该菌治疗的首选药物 ,提示与老年、有基础病及并发症、广谱抗生素及激素应用、呼吸道侵袭性操作、呼吸器具及空气消毒不严格有关。
OBJECTIVE To explore the distribution and the drug tolerance of Flavobacterium infection in the authors′ hospital for recent 5 years. METHODS Isolation and identification of Flavobacterium with Bio-Merieux products VITEK-AMS60 all-automatic microbiology analysis system and its G - bacilli identification cards (GIN) and drug sensitivity cards (GNS) were done. RESULTS It was discovered that the patients from respiratory department,ICU and neurosurgery department were infected and they had the history about oxygen aspiration,sputum aspiration,trachea intubations and machinery ventilation. More than 95% of the bacilli were tolerant to imipenem. More than 90% of the bacilli were sensitive to cefotaxime,ceftriaxone,aztreonam,gentamicin and amikacin. The sensitivity rates to cefoperazone/sulbactam,ciprofloxacin,levofloxacin,trimethoprim/ sulfamethoxazole,piperacillin and piperacillin/tazobactam were relatively low (<60%). CONCLUSIONS The nosocomial infection rate of Flavobacterium has the tendency to increase year by year and its drug tolerance becomes higher. Cefoperazone/sulbactam and piperacillin/tazobactam are the first choice drugs to the bacilli. The results show that it is relative to that the patients are elder,there are underlying diseases and complications,broad spectrum antibiotics and hormones are applied,invasive operation is made on respiratory duct,sterilization of respiratory instrument and air is not strict.
出处
《中华医院感染学杂志》
CAS
CSCD
2004年第5期579-581,共3页
Chinese Journal of Nosocomiology
关键词
黄杆菌属
医院感染
耐药性分析
Flavobacterium
Nosocomial infection
Drug tolerance analysis
