摘要
目的 :探讨急性脑血管病发生应激性溃疡出血的某些因素及奥美拉唑治疗作用。方法 :选择急性脑血管病患者 112例 ,其中脑出血患者组 4 8例 ,脑梗死组 6 4例 ,留置胃管引流 ,观察急性应激后胃液 pH及应用奥美拉唑治疗后的变化。结果 :脑出血患者应激性溃疡出血的发生率明显高于脑梗死组 (P <0 .0 1) ,有消化道溃疡病史者应激性溃疡出血率显著高于无溃疡病史患者 (P <0 .0 5 ) ,脑出血患者胃液 pH值明显降低 ,奥美拉唑治疗后 ,止血总有效率和平均止血时间均较脑梗死组低及时间长 (P <0 .0 5～ 0 .0 1)。结论 :本研究结果表明 :应激性溃疡与急性脑血管病的严重程度有关 ,有消化道溃疡病史患者急性应急时更易引起出血 ,胃液 pH值持续低的患者 ,奥美拉唑疗效差 ,出血不易控制 。
Objective:To investigate some factor of stress ulcer hemorrhage complicated with acute cerebral vascular disease and the therapeutic effect of Omeprazole. Methods:A total of 112 patients with acute cerebral vascular disease were designed in the encephalorrhagia group (48 cases), the cerebral infarction group (64 cases). The level of pH of gastric fluid was examined after acute stress and treatment with Omeprazole. Results:The incidence rate of the stress ulcer hemorrhage in the encephalorrhagia group was significantly higher than that in the cerebral infarction group (P<0.01). The bleeding rate of the stress ulcer in patients satisfied the history of digestive ulcer was notably higher than those in no history of digestive ulcer (P<0.05). In the encephalorrhagia group the level of pH gastric fluid was obviously lower; the total haemostatic effective rate was lower and the average haemostatic time was longer than in the cerebral infarction group after treatment with Omeprazole (P< 0.05～0.01). Conclusion: The results suggested: The stress ulcer is related with serious degree of acute cerebral vascular disease, the patients satisfied the history of digestive ulcer are more likely suffered from ulcer hemorrhage in acute stress. As for the cases whose pH of gastric fluid is low continuously and the therapeutic effect of Omeprazole are not satisfied. The hemorrhage is hard to be controlled and the prognosis is poor.
出处
《青海医药杂志》
2004年第3期5-7,共3页
Qinghai Medical Journal
