摘要
采用随机、双盲和有安慰剂对照的现场实验,对国产血源性乙肝疫苗减量接种的远期效果进行了观察。结果表明乙肝疫苗减量与常规剂量接种虽可产生基本相同的免疫学效果,但从保护效价和有效比率来看,减量接种的远期流行病学效果则不如常规剂量接种显著;乙肝疫苗的保护效果主要取决于接种后抗HBsGMT的高低和接种剂量,似受抗HBs应答率影响较小。
A randomized, double-blind and placebo-controlled trial was conductedto observe the long-term efficacy of vaccinations of reduced doses of Chin-ese-produced plasma-derived hepatitis B vaccine. The results shows theyaccinations of reduced doses and routine doses of hepatitis B vaccine mayinduce basically similar immunological efficacy, but according to analysesof protection rate and efficacy index, long-term efficacy of epidemiology ofvaccinations of reduced doses of the vaccine is less significant than thatof routine doses of vaccine. The Protective efficacy of hepatitis B vaccinemainly depends upon anti-HBs GMT and vaccination dose, but the influenceover the protective efficacy caused by Anti-HBs response rate is negligible.
出处
《解放军预防医学杂志》
CAS
北大核心
1992年第5期352-357,共6页
Journal of Preventive Medicine of Chinese People's Liberation Army
关键词
乙型肝炎
疫苗
hepatitis B vaccine
vaccination of reduced doses
anti-HBs
Long term efficacy
