摘要
目的 :探讨高龄老年人 2 4h尿钠排泄特点 ,为防治老年钠代谢紊乱提供依据。方法 :我院老年病房 80岁以上老年 4 2例 ,根据肌酐清除率分为肌酐清除率正常组及异常组。另选中年组 2 4人及老年组 31人作为对照。所有患者均检测 2 4h尿钠、钾、磷、肌酐及肌酐清除率。结果 :①高龄组肌酐清除率低于中年组及老年组 ,2 4h尿钠排泄量亦较中年组及老年组减少 ;高龄组中肌酐清除率异常组的 2 4h尿钠排泄量较肌酐清除率正常组显著减少。②中年组与老年组尿钠排泄和肌酐清除率无相关关系 ,高龄组尿钠排泄与肌酐清除有直线相关关系 ;高龄组肌酐清除率正常组肾脏排钾保钠能力减退、尿钠排泄增加 ,肌酐清除率异常组钾、钠排泄均减少 ;③三组的钠摄入量均在 6g以上。结论 :高龄老年 2 4h尿钠排泄与肌酐清除率呈直线相关关系。当肾功能处于代偿阶段时 ,钠排泄增多 ,但严重肾功能不全时尿钠排泄减少。
Aim: To explore the characteristics of the urinary excretion in the elderly patients and to offer some advice for the prevention and treatment of hyponatremia in the elderly patients. Methods: 42 inpatients aged over 80 were divided into tow groups according to their creatinine clearance rate (CCR). Meanwhile, 24 patients aged 45～59 and 31 patients aged 60～79 were chosen as the control groups. All patients were examined 24h urinary electrolytes and CCR. Results: ① The CCR in the elderly group was lower than in the middle-aged and old group and the 24 h urinary sodium excretion was accordingly diminished than the two groups. 24 h urinary sodium excretion in CCR abnormal group was also diminished than in CCR normal group. The urinary sodium excretion was not li- nearly correlate with the CCR in middle-aged group and old group but was linearly correlate in the elderly group. ②The elderly patients' capability of holding blood sodium and excreting potassium was declined in the CCR normal group. But the urinary excretion of sodium, potassium and phosphonium were all diminished in CCR abnormal group. ③ All patients' sodium intake was higher than the criteria made by China Hypertension Association. Conclusion: Their urinary sodium excretion is linearly correlate with CCR. Urinary sodium excretion is increased when the elderly patients' renal function is relative normal but when the renal function is severely da- maged, urinary sodium excretion is diminished.
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2004年第2期185-188,共4页
Chinese Journal of Applied Physiology
关键词
钠离子
代谢紊乱
高龄老年
尿钠排泄
elderly men
urinary sodium excretion
characteristics
