摘要
目的 探讨血清中抗氧化型低密度脂蛋白 (ox LDL)抗体、抗 β2 糖蛋白I(β2 GPI)抗体及抗内皮细胞抗体 (AECA) 3种自身抗体与动脉粥样硬化的关系。方法 分别用酶联免疫吸附法(ELISA)和间接免疫荧光法 (IIF)检测 118例冠状动脉硬化性心脏病患者及 4 4名健康对照者血清中 3种自身抗体水平。结果 冠心病组血清抗ox LDL抗体阳性率为 32 2 0 % ,明显高于健康对照组阳性率 6 82 % (P =0 0 0 1) ;抗 β2 GPI抗体阳性率为 31 36 % ,其健康对照组阳性率为 11 36 % (P =0 0 0 9) ;血清抗内皮细胞抗体阳性率冠心病组为 38 14 % ,健康对照组为 13 6 4 % (P =0 0 0 2 )。在血脂正常的冠心病组中抗ox LDL和抗β2 GPI抗体阳性率也高于健康对照组。结论 血清中上述 3种自身抗体阳性率与动脉粥样硬化密切相关 ,抗ox LDL和抗 β2 GPI抗体阳性率与血脂无明显相关性 ,自身免疫反应是动脉粥样硬化的一种可能的发病机制。
Objectives To explore the relationship between the positive rates of serum anti-ox-LDL、anti-β 2GPI 、anti-endothelial cell autoantibodies (AECA) and atherosclerosis. Methods The levels of serum anti-ox-LDL and anti-β 2GPI antibodies were measured by ELISA. The serum AECA was assayed by indirect immunofluorescence (IIF) in 118 patients with coronary arteriosclerosis disease(CAD) and 44 controls without CAD. Results The positive rates of serum anti-ox-LDL、anti-β 2GPI and AECA in CAD group were significantly higher than that in control.(30.20% versus 6.82%, P=0.001; 31.36% versus 11.36%, P=0.009; 38.14% versus 13.64%, P=0.002,respectively); In addition, the positive rates of serum anti-oxLDL and anti-β 2GPI were higher in CAD patients with normal level of plasma lipids than that in control. Conclusions The positive rates of serum anti-oxLDL 、anti-β 2GPI and AECA are related to atherosclerosis. Autoimmune reaction might play an important role in the pathogenesis of atherosclerosis.
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2004年第2期82-84,共3页
Chinese Journal of Laboratory Medicine
基金
国家自然科学基金资助项目 (3 0 0 80 0 2 7)
上海市科技发展基金资助项目 (0 2JC14 0 0 5 )
