摘要
目的 探讨大剂量多巴酚丁胺负荷试验下脉冲多普勒组织成像技术 (PW DTI)评价左心室长轴局部心肌收缩功能的临床价值。方法 冠心病患者 3 0例 (至少 1支冠状动脉主支狭窄≥ 5 0 % ) ,对照组 2 5例 ,均行大剂量多巴酚丁胺负荷试验 ,分别于静息、峰值负荷下将PW DTI取样容积置于侧壁、室间隔、前壁、下壁心肌基底段、中段心内膜下心肌采样 ,获取各节段心肌运动速度曲线。PW DTI测量指标 :收缩期峰值运动速率 (Vs)、收缩期达峰时间 (timetopeakvelocity ,TPV)、收缩期速度时间积分 (velocity timeintegral,VTI)。 结果 根据多巴酚丁胺负荷超声心动图及冠状动脉造影结果将冠心病组患者心肌节段区分为正常节段与缺血节段。与对照组相应节段 (正常组 )比较 ,静息状态下 ,冠心病缺血节段组与正常组节段间Vs、TPV、VTI并无统计学差异 ;峰值负荷下冠心病缺血节段组各节段Vs、VTI明显减低 (P <0 .0 5 ) ,而TPV则显著延长 (P <0 .0 5 )。结论 PW DTI能准确评价多巴酚丁胺负荷试验中左室长轴局部心肌收缩功能 ,从而准确无创检测冠心病缺血心肌。
Objective To evaluate left ventricular regional systolic function of long axis by pulsed wave Doppler tissue imaging (PW DTI) combined with high dose dobutamine stress echocardiography (DSE).Methods DSE was performed in 30 patients with coronary artery disease(CAD), each had at least one coronary artery ≥50% stenosis,and 25 healthy controls.In stage of baseline and peak stress,PW DTI sample volume was located on the endomyocardium at basal and middle segments of each wall.PW DTI indices included peak velocity of systolic wave (Vs),time to peak velocity (TPV) and velocity time integral (VTI).Results Segments of patients with CAD were divided into normal and ischemic segments by conditional DSE and coronary angiography.At baseline,there was no significant difference between the corresponding segments of normal controls (normal group) and ischamia of patients with CAD (ischemia group).Compared with normal group,ischemia group had significantly decreased Vs (P< 0.05 )and VTI(P< 0.05 ),delayed TPV(P< 0.05 ).Conclusions PW DTI combined with high dose DSE can correctly evaluate left ventricular regional systolic function of long axis and detect ischemic myocardium.
出处
《中华超声影像学杂志》
CSCD
2004年第1期15-19,共5页
Chinese Journal of Ultrasonography
基金
湖北省卫生厅课题 (WJ0 1 557)
