摘要
目的:探讨MMP-9和Cath-D阳性与胃癌生物学行为的关系。方法:采用免疫组化S-P法,检测MMP-9和Cath-D在128例原发性胃癌的阳性率。结果:128例胃癌组织中MMP-9和Cath-D阳性表达与胃癌生长方式、浸润深度、TNM分期、淋巴结转移密切相关(P<0.05);弥漫型胃癌MMP-9阳性率明显高于肠型胃癌(P<0.01);MMP-9和Cath-D阳性的胃癌患者五年生存率较阴性者低(P<0.05);两者在胃癌中阳性呈正相关,MMP-9(-)/Cath-D(-)组发生淋巴结转移和浆膜浸润的比率均明显低于MMP-9(+)/Cath-D(+)组、MMP-9(+)/cath-D(-)组和MMP-9(-)/Cath-D(+)组(P<0.05)。结论:MMP-9和(Sath-D与胃癌的生长、浸润、转移及预后均有密切关系,同时进行MMP-9和Cath-D免疫组化检测对于评估胃癌的预后有意义。
Purpose: To explore the relationship between positive MMP-9, Cath-D and biological behaviors in gastric carcinoma( GC). Methods: Positive MMP-9 and Cath-D were detected with S-P immunohistochemical method in 128 primary tumor specimens. Results: The positive rates of MMP-9 and Cath-D in 128 cases of human GC were correlated with growth pattern, depth of invasion, TNM categories, lymph nodes metastasis(P <0. 05). The positive rate of MMP-9 in diffuse-type carcinoma was much higher than that of intestinal-type. Five-year survival rate was significantly lower in MMP-9 or Cath-D positive GC than that in negative GC(P<0. 05) . Direct correlation was observed in GC between these two positives. The probability of lymph node metastases and serosal involvement in patients with MMP-9(- ) /Cath-D( - ) was lower than that in patients with MMP-9 ( + ) /Cath-D ( + ) or MMP-9 ( + ) /Cath-D ( - ) or MMP-9 ( - ) /Cath-D ( + ) ( P < 0. 05). Conclusions: The results demonstrate that MMP-9 and Cath-D are closely related to the growth, invasion metastasis and prognosis of GC. It is more significant for prognosis when MMP-9 and Cath-D are examined by using immunohistochemical staining at the same time.
出处
《中国癌症杂志》
CAS
CSCD
2004年第2期131-134,共4页
China Oncology
