摘要
目的 探讨真菌感染以及真菌特异性IgE对过敏性皮炎的致病作用。 方法 采用Biowhittaker变态反应诊断仪检测 136例过敏性皮炎患者血清真菌特异性IgE(sIgE) ,将其分为两组 :真菌感染组 96例 ,为合并真菌感染的过敏性皮炎患者 ,其中荨麻疹 4 5例 ,湿疹 30例 ,特应性皮炎 2 1例 ;对照组 4 0例 ,来自无合并真菌感染的过敏性皮炎患者。结果 真菌感染组中 ,血清真菌sIgE阳性率为 87.5 % ( 84 / 96 ) ,显著高于对照组 ( 14 / 4 0 ,阳性率 35 .0 % ) ,血清真菌sIgE检出率在两组病人中差异有显著性意义 ( χ2 =38.0 8,P <0 .0 0 5 ) ,真菌感染组荨麻疹、湿疹、特应性皮炎患者血清真菌sIgE的阳性检出率差异无显著性意义 ( χ2 =2 .2 4 ,P >0 .0 5 )。结论 真菌感染灶中真菌可能成为变应原刺激机体产生特异性IgE ,真菌感染在过敏性皮炎的发病机制中占重要地位。
Objective To investigate the roles of fungus infection and fungus specific IgE (sIgE) antibodies in the pathogenesis of allergic dermatitis. Methods The study was performed at 96 patients with fungus infection suffering from urticartia (45 cases), eczema (30 cases) and atopic dermatitis (21 cases), respectively. 40 allergic dermatitis patients without fungus infection as control group were studied too. The serum of suspected patients were collected, then the concentration of fungal sIgE antibodies in them were measured and analyzed by allergy diagnostic apparatus (Biowhittaker, American). Results The fungal sIgE antibody positive rate was 87.5% in fungus infection group, which was evidently higher than that of control group(35.0%) .The Chi square test confirmed the influence of fungus infection without statistical significance among urticartia, eczema and atopic dermatitis in fungus infection group (P>0.05). Conclusions The results clarified the role of fungus infection as allergens in allergic dermatitis, it also suggested that specific IgE antibodies to the fungus may play a important role in pathogenesis of allergic dermatitis.
出处
《合肥医学院学报》
2004年第1期24-25,共2页
Journal of Zunyi Medical University
关键词
真菌
感染
免疫球蛋白E
皮炎
湿疹
fungus
infection
immunoglobulin E
dermatitis
eczema
