摘要
目的研究胃肠道间质瘤(gastrointestiral stromal tumor, GIST)的临床病理特点及免疫组化特性,探讨其诊断标准和免疫组化在诊断中的价值。方法对55例GISTs进行观察,应用免疫组化(S-P法)染色检测CD117,CD34,S100,Vi,Actin,共5种免疫标记物在肿瘤中的表达。结果GIST有梭形细胞和上皮样细胞两种基本成份。有良性、交界性和恶性3种分化并有单项和复项分化能力。该组55例GISTs中有良性13例,交界性11例,恶性31例。肿瘤最大直径≥5cm,核分裂像数≥5/50HPF两项在良、恶性之间差异有显著意义。免疫组化的阳性表达结果是:CD11739例(71%)、CD34,45例(82%)、S-10019例(35%)、vimentin32例(58%),Actin6例(11%)。在形态上GIST与平滑肌瘤和神经鞘瘤难以区别,应用CD117等多种免疫组化标记是非常必要的。结论GIST是消化道一组常见的间叶组织肿瘤,有多种分化的形态,在诊断时需依靠免疫组化标记法与其它非上皮性肿瘤鉴别。
Objective: To study the clinicopathologic features and immunohistochemical speciality of the gastrointestinal stromal tumors(GISTs),and explore their criterion and value of the immunohistochemical stain in the diagnosis. Methods: Fifty-five GISTs cases were elected immunohistochemical assays of vimentin were used to study the specimen. Results: The tumor showed two basic cell compositions with elongated spindle cells and epithelioiel cell. There were three classifications benign, borderline and malignant, and differentiaions with single or multiple tissues. Morphologic ceiterentia of malignancy were tumor size>5cm,mitotic rate>5/50HPF.Immunohistochemical straining results: CD117 positive in 39 case (71%), CD34 in 45case (11%). In morphology it was difficult for GISTS to be differentiated from leiomyomas and schwannomas It was very necessary to use a series of immunohistochemical markers, especially CD117 antibody. Conclusions: GISTs are the most common group of mesenchymal tumors that arise in the wall of the gastrointestinal tract and express various differentitions and morphologies. It is necessary to distinguish other tumors from the nonepithelial neoplams of gastrointestinal tract, which is dependent on immunohistochemical features
出处
《中国现代医学杂志》
CAS
CSCD
2004年第8期93-95,100,共4页
China Journal of Modern Medicine
关键词
胃肠肿瘤
病理学
免疫组化学
gastrointestinal neoplasms
pathology
immunohischemistry CLC number: R735 Document code: A
