摘要
探讨十二指肠液γ-谷氨酰转肽酶(γ-GT)活性对新生儿阻塞性黄疸的鉴别诊断价值。应用婴儿十二指肠引流管收集38例新生儿期阻塞性黄疸的十二指肠液,检测十二指肠液中γ-GT活性。结果显示,随访黄疸消退的22例新生儿肝炎患儿,胆汁中胆红素值≥8.5μmol/L),胆汁酸阳性,γ-GT≥20Iu/L;16例肝外胆道闭锁者无胆汁,十二指肠液胆红素值0～5μmol/L,胆汁酸阴性,十二指肠液γ-GT缺如。测定十二指肠液胆红素、胆汁酸和γ-GT活性有助于早期鉴别诊断新生儿肝炎与肝外胆道闭锁。
Objective To evaluate the value of duodenal fluid γ-glutamyltranspeptidase activity in the differential diagnosis between neonatal hepatitis and biliary atresia. Methods Thirty-eight neonates who had obstructive jaundice(26 male, 12 famale) underwent duodenal fluid collection by Infantile duodenal tube. The duodenal fluid bilirubin and γ-glutamyltranspeptidase activity were measured. Rusults Twenty-two patients diagnosed as neonatal hepatitis, their bile bilirubin concentratio≥8.5μmol/L, bile acid pasitive and γ-glutamyltranspeptidase≥20 Iu/L, while 16 patients diagnosed as biliary atresia their, duodenal fluid bilirubin concentration<5μmol/L, bile acid and γ-glutamyltranspeptidase negative. Conclusion The measurement of bilirubin, bile acid and γ-glutamyltranspeptidase concentration in duodenal fluid is helpful in the differential diagnosis of neonatal hepatitis and biliary atresia.
出处
《新生儿科杂志》
CAS
2004年第2期49-51,64,95,共5页
The Journal of Neonatology
