摘要
本文将定性地考察下面的假设:在广泛散布的有丝分裂的内皮细胞和健康细胞之间,存在着直径为20毫微米的缝隙,它是白蛋白或更大分子进入血管壁的主要通道,在目前的分析中,作者定性地证实了这一漏的缝隙能够产生在哺乳动物中测量得到的渗透性高度局部化的区域,即所谓兰色区域。本文第一部分提出短时间扩散模型,预示在漏的缝中和出口附近的组织中标记物的浓度随吋间的发展,以便对证实上述假设的实验提供指导。第二部分提出描述较长时间动脉血管中大分子的非定常扩散模型及其时间趋于无穷的定常解,对不同参数进行了计算并进行了分析。
In this two part study we shall quantitatively explose the hypothesis that fully open 20 nm intercellular clefts between widenly scattered mitotic endithelial cell are main pathway of macromolecules through endothelial. In the resent analysis, the authors heve quantitatively demonstrated that this open junction pathway could also account for the localized differences in measured macromolecular permeability in mammalian arteries in so called blue areas. In part 1 of the study we shall present a model to predict the short time labeling of the leaky junction and the local subendothelial space in the first few minutes following the introduction of the tracer molecules in order to guide experiment. In part 2 of the study, we shall present a model to describe the longer time labeling of arterial media and the transiant approch to study state behavior. We have solved the mathematical problem and obtained calculating results for different parameters.
出处
《力学学报》
EI
CSCD
北大核心
1989年第3期290-299,共10页
Chinese Journal of Theoretical and Applied Mechanics
关键词
大分子
传质
非定常
血管壁
扩散
unsteady transport, macromolecules diffusion, the model of arterial wall transport
