摘要
本研究采用家兔失血性休克模型,对回盲部肠道菌群生态学的变化及其在内源性感染发病中的作用进行了初步探讨。结果发现:1.休克组动物4天存活率为50.0%,对照组无一例死亡;2休克后早期菌群无异常改变,48小时肠杆菌明显增多。休克死亡者拟杆菌与肠杆菌比值显著低于休克存活者及对照组(P<0,01);3.休克死亡动物血液细菌培养伤后持续阳性,检出菌与肠道优势生长菌一致,而休克存活者48小时血培养转为阴性。本实验表明:创伤休克可引起肠道菌群发生生态平衡失调,肠道菌群紊乱能促进肠道细菌易位与肠源性感染的发展,加剧宿主的脓毒状态,在导致休克的不可逆中具有一定的意义。
Rabbits with hemorrhagic shock were used as animalmodels.A preliminary investigation on the ecologicchange of the ileocecal bacterial flora and its role in thepathogenesis of endogenous infection.The results were asfollows:(1)The four-day survival rate of the group withshock was 50%,but no animal died in the control group.(2)There was no obvious alternation of the intestinal flo-ra in the early stage of shock.However,enteric bacillipopulation levels in the contents of ileocecum weremarkedly increased 48 hours after shock.The ratio of thepopulation level of bacteroides to that of enteric bacilli inthe nonsurvival animals after shock appeared to be signifi-cantly lower than the survivals and the control group(p<0.01).(3)The incidence of positive blood culture re-(?)ined high in the nonsurvivals while it became negativein the survivals 48 hours after shock.The results suggestthat hemorrhagic shock may cause ecologic imbalance ofthe intestinal flora,and the disturbance of intestinal floramay promote bacterial translocation and the developmentof enterogenous infection,and exacerbate the septic statusof the host,thus contributing to the occurrence of irre-versibility in shock.
出处
《中国危重病急救医学》
CAS
CSCD
1992年第3期131-133,共3页
Chinese Critical Care Medicine
