摘要
为探讨血管紧张素Ⅱ 1型受体基因A116 6 /C多态性与不同血清总胆固醇水平高血压病及其左心室重构的关系 ,测定 14 8名高血压病患者和 16 4名正常血压对照者的血压、身高、体重、空腹血糖、总胆固醇、甘油三酯浓度 ;测定高血压患者的左心室重量指数 ;聚合酶链反应—限制片长多态法鉴定血管紧张素Ⅱ 1型受体基因 116 6位点基因型 ;卡方检验分析病例组与对照组间基因型及等位基因频率 ,危险因素分析采用Logistic回归。结果发现 ,高血压组血管紧张素Ⅱ 1型受体基因AC/CC基因型频率高于对照组 (0 .2 0 3比 0 .0 10 4 ,P <0 .0 5 ,OR为 1.998,95 %CI为 1.0 73～ 3.5 81) ,116 6C等位基因频率显著高于对照组 (0 .111比 0 .0 5 5 ,P <0 .0 5 )。按总胆固醇水平进行分组统计时发现 ,在总胆固醇增商的高血压组血管紧张素Ⅱ 1型受体AC/CC基因型频率显著高于正常血压对照组 (0 .2 6比0 .0 92 ,P <0 .0 1,OR为 3.4 6 ,95 %CI为 1.2 9～ 9.2 9)。此结果表明 ,AC/CC基因型是高血压病的危险因素 ;该基因型及总胆固醇是高血压左心室重构的危险因素 ;胆固醇与血管紧张素Ⅱ 1型受体基因AC/CC基因型在高血压及其左心室重构的发生发展中可能存在协同作用 ,对血脂、血压的有效控制可能减少高血压靶器官损伤。
Aim To investigate the relationships between essential hypertension, hypertensive left ventricular remodeling, serum total cholesterol and the polymorphism of angiotensin Ⅱ type 1 receptor (AT1R) gene. Methods A case-control study was carried out using 148 hypertensive and 164 normotensive subjects. Blood pressure, body mass index, fasting serum glucose, serum total cholesterol (TC) and triglyceride (TG) were measured in all subjects, and LVMI of the hypertensives were measured. The A/c variant at position 1166 of the AT1R gene was identified by polymerase chain reaction and restriction fragment length polymorphism (PCR/RFLP) analysis. The frequencies of AC/CC genotypes and 1166C allele of AT1R gene between hypertensives and normotensives were analyzed by Chi-Square test. Results The frequencies of AC/CC genotypes and 1166C allele of AT1R gene in hypertensives were higher than that in control (AC/CC genotypes 0.203∶0.0104,P<0.05; Callele 0.111∶0.055,P<0.05),the OR is 1.998(95%CI: 1.073～3.581). More statistically significant of C1166 allele frequency and the AC genotype distribution were obtained in subjects with hypercholesterolemia when serum TC level was hierarchically analyzed (AC/CC genotypes 0.260∶0.092,P<0.01; C allele 0.144∶0.046,P<0.01), the OR reach to 3.46(95%CI: 1.29～9.29). AC/CC genotypes were risk factors to hypertension, and such genotypes and TC were risk factors to hypertensive left ventricular remodeling. Conclusions 1166AC/CC genotypes of AT1R gene and TC have additive relation with essential hypertension and hypertensive left ventricular remodeling, the effective control of TC and blood pressure might decrease the damage of target organs.
出处
《中国动脉硬化杂志》
CAS
CSCD
2004年第1期57-60,共4页
Chinese Journal of Arteriosclerosis
基金
广东省医学科技研究基金项目 (A2 0 0 0 63 2 )资助
