摘要
对21例患骨质疏松症的绝经后妇女,使用密钙息治疗。60岁以上9例,平均年龄69.6±7.5岁。60岁以下12例,平均年龄55.4±2.8岁。平均绝经年限16.3±8.3年。12例患者有骨质疏松性腰背痛,9例无症状。密钙息给药途径肌注18例,鼻喷3例,疗程3个月。结果提示,密钙息对缓解骨质疏松症引起的骨痛有效。用药前后空腹尿钙(Ca)与肌酐(Cr)比值显著下降。0.14±0.08及0.07±0.04(P<0.005)。5例定量CT(QCT)及8例单光子骨密度仪(SPA)查骨密度(BMC)无变化。其值分别为QCT76.6±24.1mg/cm^3及76.3±13.0mg/cm^3,SPA 为0.50±0.10g/cm^2及0.50±0.10g/cm^2。肌注密钙息的主要副作用为胃肠道症状及面部潮红。鼻喷用药无副作用。
21 postmenopausal females com-pleted the study.The average ageis 61.8±8.9 years.12 cases sufferedlow—back pain and 9 cases withoutsymptoms.18 patients were admi-nistered Miacalcic 100iu intramus-cularly 3 times a week,and patien-ts by nasal spray 100iu daily.All patients were treated for 3months.The results of studysuggest that:11 of 12 cases withbone pain have got to alleviatebone pain.The fasting urinecalcium/creatinine is singnificantlower than pretreatment.The meanvalue is 0.14±0.08 and 0.07±0.04(P<0.005).Bone mass measure-ments were performed by singlephoton absorptiometry(SPA)atthe distal forearm in 8 patientsand with Q—CT screening in 5cases.There were no changes foundbetween pretreatment and post—treatment of Miacalcic.The sideeffects of Miacalcic were nausea,vomiting and flushing in intramu-scular injections,no side effecthas been found in nasal spraygroup.
