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前列腺干细胞抗原与相关癌症的研究进展 被引量：1

Prostate Stem Cell Antigen and Related Cancers
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摘要 前列腺干细胞抗原 (PSCA)为一种细胞表面抗原 ,在正常前列腺中表达 ,在前列腺癌、膀胱癌及胰腺癌组织中过度表达。PSCA在前列腺癌监测中敏感性优于PSA。PSCA可用于制备蛋白疫苗和基因疫苗 ,为癌症诊断与治疗提供新的方向与思路 ;进一步研究可以明确其有效性与安全性。 Prostate stem cell antigen (PSCA) is a cell surface antigen expressed in normal prostate and overexpressed in cancers associated with prostate, bladder and pancreas. The sensitivity of PSCA labeling is higher than PSA in prostate cancer. PSCA can be used in the preparation of protein vaccine and nucleic acid vaccine. Further studies are required to confirm its safety and efficacy as a diagnostic means.
作者 舒勇 孙丹宁
机构地区 中国人民解放军第
出处 《中华男科学杂志》 CAS CSCD 2004年第5期382-384,共3页 National Journal of Andrology
关键词 干细胞抗原 前列腺 癌 stem cell antigen prostate cancer
分类号 R730.4 [医药卫生—肿瘤]
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参考文献25

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同被引文献23

  • 1王振林,王笑芳.血清前列腺特异性抗原与碱性磷酸酶测定在判断前列腺癌骨转移中的价值[J].中华男科学杂志,2005,11(11):825-827. 被引量：4
  • 2Roudier MP, Vesselle H, True LD, et al. Bone histology at autopsy and matched bone scintigraphy findings in patients with hormone refractory prostate cancer: The effect of bisphosphonate therapy on bone scintigraphy results, Clin Exp Metastasis, 2003, 20 ( 2 ) : 171-180.
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  • 7Bubendorf L, Schopfer A, Wagner U, et al. Metastatic patterns of prostate cancer: An autopsy study of 1589 patients. Hum Pathol, 2000, 31(5): 578-583.
  • 8Chen N, Ye XC, Chu K, et al. A secreted isoform of ErbB3 promotes osteoneetin expression in bone and enhances the invasiveness of prostate cancer cells. Cancer Res, 2007, 67 (14) : 6544- 6548.
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中华男科学杂志
2004年 第5期

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